Project description:To investigate the molecular changes and mechanism during loss of Pold3, Pold3 induble-knockout embryonic stem cells at different passages were subjected to RNA-seq analysis. We found that aberrant cell cycle and defective DNA repair were induced by loss of Pold3.
Project description:Histones were isolated from brown adipose tissue and liver from mice housed at 28, 22, or 8 C. Quantitative top- or middle-down approaches were used to quantitate histone H4 and H3.2 proteoforms. See published article for complimentary RNA-seq and RRBS datasets.
Project description:To understand the mechanisms through which JunB regulates Tregs-mediated immune regulation, we examined the global gene expression profiles in the JunB WT and KO Tregs by performing RNA sequencing (RNA-seq) analysis.
