Dataset Information


Homo sapiens

ABSTRACT: Early transcriptome profiling of microRNA-mediated neuronal reprogramming [RNA-seq timecourse]

ORGANISM(S): Homo sapiens  



Dataset's files

Action DRS
SRR5879100.fastq.gz Fastqsanger.gz
SRR5879101.fastq.gz Fastqsanger.gz
SRR5879102.fastq.gz Fastqsanger.gz
SRR5879103.fastq.gz Fastqsanger.gz
SRR5879104.fastq.gz Fastqsanger.gz
Items per page:
1 - 5 of 10
altmetric image


MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts.

Abernathy Daniel G DG   Kim Woo Kyung WK   McCoy Matthew J MJ   Lake Allison M AM   Ouwenga Rebecca R   Lee Seong Won SW   Xing Xiaoyun X   Li Daofeng D   Lee Hyung Joo HJ   Heuckeroth Robert O RO   Dougherty Joseph D JD   Wang Ting T   Yoo Andrew S AS  

Cell stem cell 20170901 3

Directed reprogramming of human fibroblasts into fully differentiated neurons requires massive changes in epigenetic and transcriptional states. Induction of a chromatin environment permissive for acquiring neuronal subtype identity is therefore a major barrier to fate conversion. Here we show that the brain-enriched miRNAs miR-9/9<sup>∗</sup> and miR-124 (miR-9/9<sup>∗</sup>-124) trigger reconfiguration of chromatin accessibility, DNA methylation, and mRNA expression to induce a default neurona  ...[more]

Similar Datasets

2013-01-01 | S-EPMC4100556 | BioStudies
| PRJNA396263 | ENA
1000-01-01 | S-EPMC4471828 | BioStudies
2014-01-01 | S-EPMC4274867 | BioStudies
2018-01-01 | S-EPMC5954199 | BioStudies
2013-01-01 | S-EPMC3622290 | BioStudies
2013-01-01 | S-EPMC3552026 | BioStudies
2012-01-01 | S-EPMC3448669 | BioStudies
2016-01-01 | S-EPMC5094835 | BioStudies
1000-01-01 | S-EPMC6022641 | BioStudies