Dataset Information


Staphylococcus aureus USA300-0114

ABSTRACT: RNA-seq of Wildtype Staphylococcus aureus USA300 NRS384

ORGANISM(S): Staphylococcus aureus USA300-0114  



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Host-derived fatty acids activate type VII secretion in Staphylococcus aureus.

Lopez Michael S MS   Tan Irene S IS   Yan Donghong D   Kang Jing J   McCreary Mark M   Modrusan Zora Z   Austin Cary D CD   Xu Min M   Brown Eric J EJ  

Proceedings of the National Academy of Sciences of the United States of America 20171002 42

The type VII secretion system (T7SS) of Staphylococcus aureus is a multiprotein complex dedicated to the export of several virulence factors during host infection. This virulence pathway plays a key role in promoting bacterial survival and the long-term persistence of staphylococcal abscess communities. The expression of the T7SS is activated by bacterial interaction with host tissues including blood serum, nasal secretions, and pulmonary surfactant. In this work we identify the major stimulator  ...[more]

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