Dataset Information


Saccharomyces cerevisiae

ABSTRACT: Viral challenge as a potential driver of histone loss in dinoflagellates

ORGANISM(S): Saccharomyces cerevisiae  



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Viral proteins as a potential driver of histone depletion in dinoflagellates.

Irwin Nicholas A T NAT   Martin Benjamin J E BJE   Young Barry P BP   Browne Martin J G MJG   Flaus Andrew A   Loewen Christopher J R CJR   Keeling Patrick J PJ   Howe LeAnn J LJ  

Nature communications 20180418 1

Within canonical eukaryotic nuclei, DNA is packaged with highly conserved histone proteins into nucleosomes, which facilitate DNA condensation and contribute to genomic regulation. Yet the dinoflagellates, a group of unicellular algae, are a striking exception to this otherwise universal feature as they have largely abandoned histones and acquired apparently viral-derived substitutes termed DVNPs (dinoflagellate-viral-nucleoproteins). Despite the magnitude of this transition, its evolutionary dr  ...[more]

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