Human gut metagenome
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA397219 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Gut metagenomes of patients with COVID-19
| PRJNA650244 | ENA
Project description:Colorectal cancer patients Targeted Locus (Loci)
| PRJNA238277 | ENA
Project description:Gut microbiome research is rapidly moving towards the functional characterization of the microbiota by means of shotgun meta-omics. Here, we selected a cohort of healthy subjects from an indigenous and monitored Sardinian population to analyze their gut microbiota using both shotgun metagenomics and shotgun metaproteomics. We found a considerable divergence between genetic potential and functional activity of the human healthy gut microbiota, in spite of a quite comparable taxonomic structure revealed by the two approaches. Investigation of inter-individual variability of taxonomic features revealed Bacteroides and Akkermansia as remarkably conserved and variable in abundance within the population, respectively. Firmicutes-driven butyrogenesis (mainly due to Faecalibacterium spp.) was shown to be the functional activity with the higher expression rate and the lower inter-individual variability in the study cohort, highlighting the key importance of the biosynthesis of this microbial by-product for the gut homeostasis. The taxon-specific contribution to functional activities and metabolic tasks was also examined, giving insights into the peculiar role of several gut microbiota members in carbohydrate metabolism (including polysaccharide degradation, glycan transport, glycolysis and short-chain fatty acid production). In conclusion, our results provide useful indications regarding the main functions actively exerted by the gut microbiota members of a healthy human cohort, and support metaproteomics as a valuable approach to investigate the functional role of the gut microbiota in health and disease.
2017-07-19 | PXD005780 | Pride
Project description:Raw Sequence Reads of Colorectal Cancer Patients
| PRJNA797640 | ENA
Project description:Gut metagenome of patients with colon cancer
| PRJNA178693 | ENA
Project description:Gut metagenomic raw sequence reads of cancer patients
| PRJNA494824 | ENA
Project description:Alterations in gut microbiota have been implicated in the pathogenesis of Colorectal Cancer (CRC). Here we collected fecal samples from 14 CRC patients and 14 healthy volunteer cohorts, and characterized their microbiota using label-free quantitative metaproteomics method. We have quantified 30,062 gut microbial protein groups, 91，902 peptides, and 195 genera of microbes, among which 341 proteins were found significantly different in abundance between the CRC patients and healthy volunteers. Our study demonstrates that gut bacteria involve in CRC pathogenesis not only via taxonomy abundance variations but also functional activity changes.
2020-02-23 | PXD013386 | iProX
Project description:Malaysia (MAL2) Cohort of Colorectal Cancer Patients with and without Biofilm Formation
| PRJNA325650 | ENA
Project description:Malaysia (MAL1) Cohort of Colorectal Cancer Patients with and without Biofilm Formation
| PRJNA325649 | ENA
Project description:Genome reconstructions from human gut metagenomes
| PRJNA312222 | ENA