Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA397881 | ENA |
REPOSITORIES: ENA
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Project description:This SuperSeries is composed of the following subset Series: GSE20680: Whole Blood Cell Gene Expression Profiling in Patients with Coronary Artery Disease from the Cathgen Registry GSE20681: Whole Blood Cell Gene Expression Profiling in Patients with Coronary Artery Disease from the PREDICT Trial Refer to individual Series
2011-03-01 | E-GEOD-20686 | biostudies-arrayexpress
Project description:Recent genome-wide association studies (GWAS) have identified gene variants associated with coronary artery disease including ADAMTS7, PHACTR1, KIAA1462/JCAD (Junctional Protein Associated with Coronary Artery Disease) and many others. JCAD has been identified as a novel component of endothelial cell-cell junctions (Akashi et al., 2011, BBRC) and regulates angiogenesis (Hara et al, ATVB, 2017). In our study, we observed that JCAD is a 148-KDa protein identified by mass spectrometry, but display a band shift to around 180-200 KDa, suggesting that JCAD is subject to multiple post-translatinonal modification. We also observed that JCAD well colocalized with adheren junction VE-cadherin, tight junction ZO-1 and desmosome junction plakoglobin (also known as gamma-catenin). However, the functional role of JCAD in endothelial function and the etiology of vascular disease remains unknown. In view of the critical role of junctional proteins in regulating endothelial function including vascular permeability, angiogenesis, and monocyte adhesion, we hypothesized that JCAD may play a crucial role in regulating endothelial function. To better understand the function of JCAD in endothelial cells, we performed RNA-sequencing based transcriptomic profiling in JCAD depleted (by transfection with by JCAD siRNA) human coronary artery endothelial cells, to identify critical genes and pathways associated with JCAD. We found that multiple atherosclerosis related genes and pathways are modulated by JCAD. Further studies are needed to characterize the biological function of JCAD in the pathogenesis of cardiometabolic diseases associated with endothelial dysfunction, such as diabetes, obesity, hypertension and atherosclerosis.
2018-08-10 | GSE102498 | GEO
Project description:human coronary artery endothelial cell Transcriptome
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Project description:Vascular endothelial cells play an important role in the development of coronary artery disease, their injury leads to coronary heart disease and atherosclerosis. This study aimed to elucidate the role of FOXO3-regulated target gene expression and alternative splicing in vascular endothelial cell injury in coronary artery disease
2024-02-09 | GSE225605 | GEO
Project description:Phenotypic heterogeneity among arterial ECs is particularly relevant to atherosclerosis since the disease occurs predominantly in major arteries, which vary in their atherosusceptibility. To explore EC heterogeneity, we used DNA microarrays to compare gene expression profiles of freshly harvested porcine coronary and iliac artery ECs. We demonstrate that in vivo the endothelial transcriptional profile of a coronary artery (the right coronary artery) is intrinsically different from that of a major conduit vessel (the external iliac artery), and that this difference is consistent with former vessel being more prone to atherosclerosis. Keywords: coronary atherosclerosis, endothelial heterogeneity, microarray, gene expression Endothelial cells were freshly harvest from right coronary, left and right iliac arteries from four pigs. RNA were isolated and expression profiles were obtained using olig microarrays.
2010-06-20 | E-GEOD-10938 | biostudies-arrayexpress
Project description:Analysis of ex vivo isolated lymphatic endothelial cells from the dermis of patients to define type 2 diabetes-induced changes. Results preveal aberrant dermal lymphangiogenesis and provide insight into its role in the pathogenesis of persistent skin inflammation in type 2 diabetes. The ex vivo dLEC transcriptome reveals a dramatic influence of the T2D environment on multiple molecular and cellular processes, mirroring the phenotypic changes seen in T2D affected skin. The positively and negatively correlated dLEC transcripts directly cohere to prolonged inflammatory periods and reduced infectious resistance of patients´ skin. Further, lymphatic vessels might be involved in tissue remodeling processes during T2D induced skin alterations associated with impaired wound healing and altered dermal architecture. Hence, dermal lymphatic vessels might be directly associated with T2D disease promotion. Global gene expression profile of normal dermal lymphatic endothelial cells (ndLECs) compared to dermal lymphatic endothelial cells derived from type 2 diabetic patients (dLECs).Quadruplicate biological samples were analyzed from human lymphatic endothelial cells (4 x diabetic; 4 x non-diabetic). subsets: 1 disease state set (dLECs), 1 control set (ndLECs)
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Project description:MIGen Exome Sequencing: Precocious Coronary Artery Disease
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Project description:MIGen Exome Sequencing: Precocious Coronary Artery Disease
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Project description:Phactr-1 is an actin and protein phosphatase 1 (PP1) binding protein which is reported to be highly expressed in brain and controls PP1 activity and F-actin remodelling. Genome-wide association studies (GWASs) implicate the Phactr-1 locus (6p24) as a risk factor for five vascular diseases, including coronary artery disease, migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension, with its mechanism of action being incompletely understood. To depict how Phactr1 regulates endothelial cell function, we performed transcriptomic profiling of human umbilical vein endothelial cells (HUVECs) infected with Phactr1 adenovirus. We documented that Phactr1 overexpression triggers multiple aspects of endothelial dysfunction, thus providing a mechanistic basis for Phactr1 mediated disease-relevant vascular functions.
2022-08-16 | GSE186761 | GEO