Genomics

Dataset Information

294

Homo sapiens


ABSTRACT: Tracing the temporal-spatial transcriptomic landscapes of the human fetal digestive tract by single cell RNA-seq analysis [adult tissues]

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA400367 | ENA |

REPOSITORIES: ENA

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Publications

Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing.

Gao Shuai S   Yan Liying L   Wang Rui R   Li Jingyun J   Yong Jun J   Zhou Xin X   Wei Yuan Y   Wu Xinglong X   Wang Xiaoye X   Fan Xiaoying X   Yan Jie J   Zhi Xu X   Gao Yun Y   Guo Hongshan H   Jin Xiao X   Wang Wendong W   Mao Yunuo Y   Wang Fengchao F   Wen Lu L   Fu Wei W   Ge Hao H   Qiao Jie J   Tang Fuchou F  

Nature cell biology 20180525 6


The development of the digestive tract is critical for proper food digestion and nutrient absorption. Here, we analyse the main organs of the digestive tract, including the oesophagus, stomach, small intestine and large intestine, from human embryos between 6 and 25 weeks of gestation as well as the large intestine from adults using single-cell RNA-seq analyses. In total, 5,227 individual cells are analysed and 40 cell types clearly identified. Their crucial biological features, including develo  ...[more]

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