Dataset Information


Mus musculus

ABSTRACT: Transcriptional profiles of female VMHpvlm and VMHpvll

ORGANISM(S): Mus musculus  



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Esr1+ cells in the ventromedial hypothalamus control female aggression.

Hashikawa Koichi K   Hashikawa Yoshiko Y   Tremblay Robin R   Zhang Jiaxing J   Feng James E JE   Sabol Alexander A   Piper Walter T WT   Lee Hyosang H   Rudy Bernardo B   Lin Dayu D  

Nature neuroscience 20170918 11

As an essential means of resolving conflicts, aggression is expressed by both sexes but often at a higher level in males than in females. Recent studies suggest that cells in the ventrolateral part of the ventromedial hypothalamus (VMHvl) that express estrogen receptor-α (Esr1) and progesterone receptor are essential for male but not female mouse aggression. In contrast, here we show that VMHvlEsr1+ cells are indispensable for female aggression. This population was active when females attacked n  ...[more]

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