Project description:To look for age-related changes in the liver that take place during DNA damage resolution, we used RNAseq gene expression analysis to characterize mRNA expression profile in livers from 1-month vs. 6-month-old mice either before or 2 days (representing the peak of DNA damage response) and 6 days (representing the resolution phase of DNA damage) after DEN treatment.
Project description:This SuperSeries is composed of the following subset Series: GSE39928: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [35MM] GSE39929: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [40MM] GSE39930: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [41MM] GSE39931: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [43MM] Refer to individual Series ** Six samples in each Series represent the same set of biological source material hybridized to 4 different arrays (named IMP internal: 35MM, 40MM, 41MM, and 43MM).
Project description:To look for age-related changes in the liver, we used RNAseq gene expression analysis to characterize mRNA expression profile in livers from 1-month vs. 6-month-old mice
Project description:Transcriptional profiling of mouse whole liver comparing control WT B6 mice with B6 growth hormone-deficient little, B6 androgen receptor-null Tfm mice, and STAT5b KOs normalized to WT on B6 and BALB/c backgrounds. All animals were 10-week-old males initiated with DEN. Oberley et al. Molecular carcinogenesis 2014 May 17. doi: 10.1002/mc.22165. Three-condition experiment, WT vs. little and Tfm livers. Biological replicates: 3 control replicates, 3 mutant replicates. Little and Tfm normalized to WTa, B6 STAT5b KO
Project description:Totally, fourteen two-month-old mice were used in the young group and ten eighteen-month-old mice were used in the old group. Their livers were detached for phosphoproteome analysis.
Project description:Transcriptome analysis comparing livers of 10 month old MANFHet mice and WT littermates revealed the induction of genes associated with inflammation, apoptosis, collagen deposition, usually observed in association with liver damage, along with alterations in lipid metabolism.
Project description:To investigate the global function of Ftcd in the regulation of hepatocarcinonegesis, we established DEN-induced or untreated liver-specific Ftcd knockout(referred as Ftcd LKO) murine model in which Ftcd has been knocked out by loxp/alb-cre system, take the wildtype(referred as WT) mice as control. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different Ftcd LKO mice and 6 different WT mice at 12 months after DEN treatment, as well as RNA-seq of 3 different 12-month-old Ftcd LKO and WT mice.
