Genomics

Dataset Information

118

Genome-wide H3K4me3 and gene expression before and after methionine restriction in human cancer cells and mouse liver


ABSTRACT: Genome-wide H3K4me3 and gene expression before and after methionine restriction in human cancer cells and mouse liver

PROVIDER: PRJNA402050 | ENA |

REPOSITORIES: ENA

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Publications

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.

Dai Ziwei Z   Mentch Samantha J SJ   Gao Xia X   Nichenametla Sailendra N SN   Locasale Jason W JW  

Nature communications 20180516 1


Nutrition and metabolism are known to influence chromatin biology and epigenetics through post-translational modifications, yet how this interaction influences genomic architecture and connects to gene expression is unknown. Here we consider, as a model, the metabolically-driven dynamics of H3K4me3, a histone methylation mark that is known to encode information about active transcription, cell identity, and tumor suppression. We analyze the genome-wide changes in H3K4me3 and gene expression in r  ...[more]

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