Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA402057 | ENA |

REPOSITORIES: ENA

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Publications

Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence.

de Morrée Antoine A   van Velthoven Cindy T J CTJ   Gan Qiang Q   Salvi Jayesh S JS   Klein Julian D D JDD   Akimenko Igor I   Quarta Marco M   Biressi Stefano S   Rando Thomas A TA  

Proceedings of the National Academy of Sciences of the United States of America 20171009 43


Tissue regeneration depends on the timely activation of adult stem cells. In skeletal muscle, the adult stem cells maintain a quiescent state and proliferate upon injury. We show that muscle stem cells (MuSCs) use direct translational repression to maintain the quiescent state. High-resolution single-molecule and single-cell analyses demonstrate that quiescent MuSCs express high levels of Myogenic Differentiation 1 (MyoD) transcript in vivo, whereas MyoD protein is absent. RNA pulldowns and cost  ...[more]

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