Project description:ChIP-seq analyses were perform to define the distribution of PITX1, SOX2 and TP63 through the genome and define their interactions in SCC
Project description:ChIP-seq analyses were perform to define the distribution of Pitx1, Sox2, Trp63 and Klf4 through the genome and define their interactions in SCC.
Project description:TGF-beta-responding SCC cells, a tumor-initiating cell population, show a unique gene expression signature, including antioxidant gene expression and IL-33 upregulation. IL-33-responding macrophages in SCC, which also express Fc epsilon receptor I alpha, show a gene expression signature that resembles alternatively-activated macrophages