Genomics

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Expression data from C57/6J mice (Normal), APP/PS1 mice and APP/PS1 mice treatment with HPYD


ABSTRACT: Expression data from C57/6J mice (Normal), APP/PS1 mice and APP/PS1 mice treatment with HPYD

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA412164 | ENA |

REPOSITORIES: ENA

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Publications

β-Sheet Breaker Peptide-HPYD for the Treatment of Alzheimer's Disease: Primary Studies on Behavioral Test and Transcriptional Profiling.

Liu Weiying W   Sun Fengxian F   Wan Moxin M   Jiang Fang F   Bo Xiangyu X   Lin Laixiang L   Tang Hua H   Xu Shumei S  

Frontiers in pharmacology 20170101


Background: Alzheimer's disease (AD), is a progressive neurodegenerative disease that is characterized by cognitive loss. Most researchers believe that aggregation and accumulation of β-amyloid peptides (Aβ) in brain cells are the central pathological hallmark of this disease. Methods: Based on the amyloid hypothesis, a 10 amino acids β-sheet breaker peptide HPYD (His-Lys-Gln-Leu-Pro-Phe-Tyr-Glu-Glu-Asp) was designed according to the structure and sequence of the previous designed peptide H102.  ...[more]

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