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Clonally expanded CD4+ T cells with a unique gene signature contribute to persistence of the HIV-1 latent reservoir

ABSTRACT: Clonally expanded CD4+ T cells with a unique gene signature contribute to persistence of the HIV-1 latent reservoir

PROVIDER: PRJNA412829 | ENA |

REPOSITORIES: ENA

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Clonally expanded CD4+ T cells with a unique gene signature contribute to persistence of the HIV-1 latent reservoir

Project description:Surface expression of the viral Envelope protein (Env) was used to enrich reactivated latent T cells producing HIV-RNA, and single cell RNASeq was performed to study gene expression differences between latent cells and controls.

2018-03-02 | GSE104490 | GEO

Clonally expanded T cells reveal immunogenicity of rhabdoid tumors

Project description:Clonally expanded T cells reveal immunogenicity of rhabdoid tumors

| PRJNA576727 | ENA

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid

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Clonally expanded T cells reveal immunogenicity of rhabdoid tumors

Project description:Clonally expanded T cells reveal immunogenicity of rhabdoid tumors

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Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [CSF]

Project description:Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [CSF]

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Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TEMRA]

Project description:Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TEMRA]

| PRJNA555620 | ENA

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TCR-seq]

Project description:Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TCR-seq]

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Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses

Project description:Antiretroviral therapy controls but does not cure HIV-1 infection due to a reservoir of rare CD4 + T cells harboring latent proviruses. Little is known about the transcriptional program of latent cells. Here we report a novel strategy to enrich clones of latent cells carrying intact, replication-competent HIV-1 proviruses from blood based on their expression of unique T cell receptors. Latent cell enrichment enabled single cell transcriptomic analysis of 1,050 CD4 + T cells belonging to expanded clones harboring intact HIV-1 proviruses from 6 different individuals. The analysis revealed that most of these cells are T effector memory cells that are enriched for expression of HLA-DR, HLA-DP, CD74, CCL5, Granzymes A and K, cystatin F, LYAR and DUSP2. We conclude that expanded clones of latent cells carrying intact HIV-1 proviruses persist preferentially in a distinct CD4 + T cell population opening new possibilities for eradication.

2022-06-03 | GSE204756 | GEO

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TEMRA]

Project description:Alzheimer’s disease (AD) is an age-related neurodegenerative disorder in which neuroinflammation plays a critical function. Recurring viral infections and loss of immune competence increase risk for developing AD, yet the cellular and molecular mechanisms driving these immune changes are unknown. Here we performed mass cytometry of peripheral blood mononuclear cells and detected an immunologic signature of AD characterized by increased numbers of CD8+ T effector memory CD45RA+ (TEMRA) cells. CD8+ TEMRA cells were negatively associated with cognition and single cell RNA sequencing revealed their cytotoxic effector function. Strikingly, we discovered identical, shared T cell receptors (TCRs) of clonally expanded CD8+ TEMRA cells in cerebrospinal fluid (CSF) of three AD patients. Deep TCR sequencing, machine learning, and peptide screens identified the HLA-B*08:01-restricted Epstein-Barr virus trans-activator protein BZLF1 as the cognate antigen of a novel AD CSF TCR . These results provide the first evidence of clonal, antigen-specific T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration

2019-11-04 | GSE134576 | GEO

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [CSF]

2019-11-04 | GSE134577 | GEO

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