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Chromatin remodeler SPLAYED maintains the balance of miR156 dependent developmental pathways in Arabidopsis

ABSTRACT: Chromatin remodeler SPLAYED maintains the balance of miR156 dependent developmental pathways in Arabidopsis

PROVIDER: PRJNA413421 | ENA |

REPOSITORIES: ENA

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Chromatin remodeler SPLAYED maintains the balance of miR156 dependent developmental pathways in Arabidopsis

Project description:In plants, micro RNAs and chromatin remodeling are both known to regulate plant development and reproduction, however evidences for molecular links between these pathways have remained sparse. The antagonistic activities of miR156 and its target mRNAs, encoding several SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors, control the juvenile-to-adult and vegetative-to-reproductive developmental phase transitions. In recent years a number of proteins were shown to act in the transcriptional control of MIR156 genes, demonstrating the complexity of the regulatory network involved in this process. Spatiotemporal control of gene expression involves interactions between transcription factors and changes in the chromatin structure. SPLAYED (SYD) is a well-characterized SWI2/SNF2 chromatin remodeling ATPase, which has been shown to be an important regulator of flowering time, flower organ identity and homeotic gene expression. In this study, we investigated the interaction between the miR156 and SYD pathways and provide evidence that SYD directly influences the transcription of several MIR156 and SPL genes in Arabidopsis. We propose that SYD maintains the balance between the miR156-dependent and miR156-independent developmental pathways. More generally, we then show that SYD may also play a very broad role in the control of gene expression by associating to most genes in Arabidopsis. We show that binding to these genes is dependent on the meristem identity factor LEAFY and the PRC2 component SWINGER. These results uncover a much more general role for SYD in regulating and balancing key developmental processes in Arabidopsis than previously assumed.

2020-10-12 | GSE104665 | GEO

INO80C chromatin remodeler prevents promiscuous transcription at replication origins

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A dual functions of autism-related chromatin remodeler CHD8 in developmental and adult neurogenesis

Project description:The loss-of-function mutations in the chromatin remodeler CHD8, a high-risk factor in autism spectrum disorder (ASD), lead to severe developmental delay, however, the underlying mechanisms remains elusive. Here, we use transcriptome and genomic occupancy reveal that CHD8 regulates chromatin accessibility and activates neurogenesis-related genes for cortical neurogenesis.

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A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte

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Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers

Project description:Using CRISPR-Cas9 to tag endogenous remodeler subunits in Drosophila melanogaster S2 cells, we demonstrate that developmental gene transcription requires SWI/SNF-type complexes, primarily to maintain distal enhancer accessibility.

2023-10-24 | PXD036007 | Pride

The human mitochondrial translatome promotes mitonuclear balance

Project description:Oxidative phosphorylation (OXPHOS) complexes consist of nuclear- and mitochondrial- encoded subunits, forcing cross-compartment synchronization of gene expression to achieve mitonuclear balance. To characterize how human cells coordinate OXPHOS gene expression, we establish a mitoribosome profiling approach that resolves features of the mitochondrial translatome, including the synthesis of a four amino acid mitopeptide. Strikingly, average mitochondrial and cytoplasmic synthesis rates correspond precisely across OXPHOS complexes. Coordinated mitochondrial and cytosolic synthesis does not require rapid feedback between the two translation systems. By contrast, we find that the Leigh syndrome gene, LRPPRC, maintains correlated mitochondrial and cytosolic translatomes. Our results lead to a model of human mitonuclear balance that requires tightly balanced cross-compartment protein synthesis, representing a vulnerability for cellular proteostasis.

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Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination.

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Temporal regulatory role of miR156 during leaf ontogenesis

Project description:Analysis of different leaves from transgenic plants over expressing microRNA miR156. Time-dependent gene expression is essential for developmental timing control. MiR156 was characterized as a time-dependent expressed microRNA during leaf development. The level of miR156 is positive correlated to developmental time during leaf growth. We used microarray to identify genes regulated by miR156 in a time-dependent manner during leaf development. Results indicate that most time-negative genes were activated in mature leaves of miR156 over expressed plants compared with wild type. Keywords: gene expression array-based (RNA / in situ oligonucleotide) To identify the temporal regulation role of miR156 in different leaves, all leaves in the main tiller were collected separately from Md/Mh (miR156 over expressed lines) and wild type (WT) plants. The level of miR156 were checked in these samples, then three biological repeats were selected and these RNA samples of the oldest (L1) and youngest leaf (L4 or L5) were applied for microarray hybridization.

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Developmental Exposure to 2,2’,4,4’-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice

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