Genomics

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Whole-Genome Methylation Profile of Fibroblast-Derived Isogenic Induced Pluripotent Stem Cells


ABSTRACT: Whole-Genome Methylation Profile of Fibroblast-Derived Isogenic Induced Pluripotent Stem Cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA414786 | ENA |

REPOSITORIES: ENA

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Methylation profile of induced pluripotent stem cells generated by integration and integration-free approaches.

Sultanov Rinat R   Lebedeva Olga O   Arapidi Georgij G   Lagarkova Maria M   Kiselev Sergei S  

Data in brief 20180131


The genetic reprogramming technology allows generation of induced pluripotent stem cells (iPSCs) from somatic cells (Takahashi and Yamanaka, 2006) [1]. iPSCs have the ability to self-renew, and to differentiate into any type of somatic cells, and are considered as a promising tool for drug development, disease modeling, and regenerative medicine. The reprogramming factors (oct4, sox2, klf4, c-myc) can be delivered to the cell nucleus either by vectors integrating into the genome (lentiviruses, r  ...[more]

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