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Gene expression signatures for eSAS (human tongue squamous-cell carcinoma cell line) compared with parental SAS

ABSTRACT: Gene expression signatures for eSAS (human tongue squamous-cell carcinoma cell line) compared with parental SAS

PROVIDER: PRJNA415920 | ENA |

REPOSITORIES: ENA

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Gene expression signatures for eSAS (human tongue squamous-cell carcinoma cell line) compared with parental SAS

Project description:To examine if gene expression level is altered in eSAS (human tongue squamous-cell carcinoma cell line) compared with that of parental SAS, we performed genome-wide DNA microarray analysis. For this purpose, we prepared total mRNAs from SAS and eSAS cells in their Log growth phase and compared their genome-wide expression levels.

2018-10-22 | GSE106207 | GEO

Human tongue squamous cell carcinoma cell：Control vs. stable METTL3 knockdown

Project description:Transcriptional profiling of human tongue squamous cell carcinoma cell comparing control untreated SAS cells with stable METTL3 knockdown SAS cells. METTL3 is an important methyltransferase in N6-methyladenosine modification. Goal was to determine the differentially expressed and methylated genes upon METTL3 knockdown.

2022-01-25 | GSE194257 | GEO

Human tongue squamous cell carcinoma cell line SAS-Control vs. SAS-LYRIC knockdown stable clones global gene profiling

Project description:Transcriptional profiling of SAS cells transfected with pLKO.1-LYRIC shRNA-B expression vector (desinaged as B) and control SAS cells (transfected with pLKO.1 vector, designated as CTL). Goal was to determine the effects of LYRIC knockdown on global SAS cells gene expression. Two-condition experiment, SAS cells transfected with pLKO.1-LYRIC shRNA-B expression vector (desinaged as B) v.s. control SAS cells (transfected with pLKO.1 vector, designated as CTL). Biological replicates: 4 control replicates, 4 transfected replicates.

2016-02-28 | E-GEOD-44766 | biostudies-arrayexpress

Human tongue squamous cell carcinoma cell line SAS-Control vs. SAS-LYRIC knockdown stable clones global gene profiling

2016-02-28 | GSE44766 | GEO

IGFBP3 contributes to cell migration and proliferation in an endophytic tongue squamous cell carcinoma cell line

Project description:We previously found that IGFBP3 mRNA levels are higher in endophytic-type human tongue squamous cell carcinoma (TSCC) that is more invasive and more prone to metastasis than exophytic and superficial types. To investigate the roles of IGFBP-3 in SAS cells that express a fluorescent ubiquitination-based cell-cycle indicator (Fucci).

2022-07-13 | GSE205275 | GEO

RNA expression in tongue squamous cell carcinoma, tumour free tongue tissue and control tongue

Project description:Tongue squamous cell carcinoma is a tumour type with rather low five year survival, around 60%. The poor survival rate has been ascribed to late detection, a high frequency of locoregional recurrence, the occurrence of secondary primary tumours and death due to comorbidity. One reason for development of recurrence is thought to be the existence of transformed cells in areas adjacent to the primary tumour, cancerization field effect. The aim of this study was to map the changes in the tumour free tongue tissue adjacent to tongue tumours compared with healthy control tongue tissue to better understand the cancerization field effect. Tissue biopsies were collected from tumour (T) and tumour free tissue adjacent to the tumour (TF) from patients with tongue squamous cell carcinoma. Control tissue was collected from latter border of the tongue of tumour free healthy volunteers (C). All samples were homogenized and RNA was extracted. The RNA was biotin labelled and run on Illumina HT-12 bead chip array.

2016-12-21 | E-MTAB-4678 | biostudies-arrayexpress

Silencing of HAI-1 in a human oral squamous cell carcinoma cell line, SAS

Project description:To examine the role of hepatpcyte growth factor activator inhibitor type 1 (HAI-1) in cancer, we analyzed effect of HAI-1 silencing on gene expression profiles of human oral squamous cell carcinoma cell line, SAS. We used short hairpin RNA (shRNA) directed against HAI-1 mRNA. We constructed retroviral vectors which showed stable and significant silencing effects on HAI-1 genes of SAS. Microarray data of the expression profiles of duplicated experiments of HAI-1-knockdown SAS with that from the control cell are shown.

2012-01-25 | GSE32142 | GEO

Gene Level Expression Profiling in human tongue squamous carcinoma cell line (SAS): gene expression profile in SAS cells transfected with scrambled control or C6orf141 mimic

Project description:Gene Level Expression Profiling in human tongue squamous carcinoma cell line (SAS): gene expression profile in SAS cells transfected with scrambled control or C6orf141 mimic

| PRJNA508780 | ENA

Gene expression profiles of oral tongue squamous cell carcinoma tissues.

Project description:Gene expression profiles of oral tongue squamous cell carcinoma tissues. Keywords: human tongue cancer, brachytherapy, biopsy sample, primary tissues

2007-03-28 | GSE4676 | GEO

Target genes of miR-361-3p in human oral squamous cell carcinoma cells, GFP-SAS

Project description:Inhibition of miR-361-3p by locked nucleic acid (LNA)/DNA antisense oligonucleotide markedly suppressed the growth of GFP-SAS cells. We explored the target genes of miR-361-3p in GFP-SAS cells using microarray analysis.

2019-10-09 | GSE138587 | GEO

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