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Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells


ABSTRACT: Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells

PROVIDER: PRJNA416057 | ENA |

REPOSITORIES: ENA

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Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells.

Pietz Grzegorz G   De Rituparna R   Hedberg Maria M   Sjöberg Veronika V   Sandström Olof O   Hernell Olle O   Hammarström Sten S   Hammarström Marie-Louise ML  

PloS one 20170921 9


Celiac disease is a chronic inflammatory disease of the small intestine mucosa due to permanent intolerance to dietary gluten. The aim was to elucidate the role of small intestinal epithelial cells in the immunopathology of celiac disease in particular the influence of celiac disease-associated bacteria.Duodenal biopsies were collected from children with active celiac disease, treated celiac disease, and clinical controls. Intestinal epithelial cells were purified and analyzed for gene expressio  ...[more]

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