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Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes

ABSTRACT: Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes

PROVIDER: PRJNA416251 | ENA |

REPOSITORIES: ENA

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Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [EKVX]

Project description:We evaluated the effect of syndecan-1 in various cell-based and animal models of lung cancer and found that lung tumorigenesis was promoted when cells lose syndecan-1 expression. We also demonstrate that syndecan-1 (or lack thereof) alters the microRNA (miRNA) cargo carried within exosomes exported from lung cancer cells. Analysis of the changes in miRNA expression identifies a distinct shift toward augmented pro-cancerous signaling, which are consistent with the changes found in lung adenocarcinoma. In all, our work identifies syndecan-1 as an important factor on lung cancer cells that control its ability to shape the lung tumor microenvironment through alterations in miRNA packaging within exosomes.

2017-10-30 | GSE106303 | GEO

Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [A549]

2017-10-28 | GSE106277 | GEO

Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [A549]

Project description:Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [A549]

| PRJNA416109 | ENA

Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [EKVX]

Project description:Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [EKVX]

| PRJNA416253 | ENA

Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-10-30 | GSE106304 | GEO

Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes.

Project description: Not available

| S-EPMC5963476 | biostudies-literature

Project description:Breast milk is a complex liquid that enriched in immunological components and affect the development of the infant immune system. Exosomes, the membranous vesicles of endocytic origin, are ubiquitously in various body fluids which can mediate intercellular communication. MicroRNAs (miRNAs), a well-defined group of non-coding small RNAs, in human breast milk are packaged inside exosomes. Here, we present the identification of miRNAs in human breast milk exosomes using deep sequencing technology. We found that the immune-related miRNAs are enriched in breast milk exosomes, and are resistant to the general harsh conditions. Four small RNA libraries in human breast milk exosomes from four healthy women (30 +/- 0.9 years old, primiparity) when the infant were aged at 60 days were sequenced.

2011-12-21 | E-GEOD-32253 | biostudies-arrayexpress

2011-12-21 | GSE32253 | GEO

Syndecan-2 and apoptosis in osteosarcoma

Project description:Syndecan-2 was found to act as a tumor suppressor in osteosarcoma and to mediate the apoptotic response to cytotoxic agents. To determine new mechanisms that control cell survival and apoptosis in osteosarcoma cells, we aim to show target genes that are involved downstream of this proteoglycan during apoptosis induction. We aim to compare the modifications induced by syndecan-2 overexpression in two different human osteosarcoma cell lines using a lentiviral vector coding the human syndecan-2. Syndecan-2 lentiviral vector (SY) and control empty lentiviral vector (VV) were transducted in two different human osteosarcoma cell lines in a dye-swap experiment.

2013-09-23 | E-GEOD-19913 | biostudies-arrayexpress

Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles (miRNA-Seq)

Project description:We studied transcriptomic changes of extracellular vesicles (EVs) in bronchoalveolar lavage fluid of bleomycin-injured wild-type and syndecan-1 deficient mice

2019-07-27 | GSE134948 | GEO

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