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Alteration in gene expression levels in glioblastoma cells in response to fractionated irradiation

ABSTRACT: Alteration in gene expression levels in glioblastoma cells in response to fractionated irradiation

PROVIDER: PRJNA418861 | ENA |

REPOSITORIES: ENA

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Alteration in gene expression levels in glioblastoma cells in response to fractionated irradiation

Project description:Analysis of alteration in gene expression levels in response to irradiation. The aim of this study was to screen genes associated with radioresistance and infiltration of glioblastoma (GBM) cells after radiotherapy. Results provide importance information of the response of GBM cells to ionizing radiation.

2017-11-17 | GSE107040 | GEO

Evaluation of Transcriptomic Change in Late-Delayed Radiation following Fractionated Whole Brain Irradiation and High Dose Total Body Irradiation in Non-Human Primates

Project description:Fractionated whole-brain irradiation for the treatment of intracranial neoplasia causes progressive neurodegeneration and neuroinflammation. The long-term consequences of high single dose brain irradiation are unknown. In order to assess the late effects of brain irradiation we have compared transcriptomic gene expression profiles from nonhuman primates (rhesus macaques, Macaca mulatta) receiving single dose total body irradiation to those given fractionated whole brain radiotherapy and control comparators. Gene expression profiles from the dorsolateral prefrontal cortex (Brodmann area 46), hippocampus, and deep white matter (centrum semiovale) were compared. The goals of this study were to identify novel potential molecular effects of radiation-induced brain injury, to evaluate regional differences in the cerebral radiation response, and to assess whether animals receiving high dose total body irradiation demonstrated similar transcriptomic patterns as those observed in animals receiving fractionated whole brain irradiation.

2019-03-27 | GSE120901 | GEO

Expression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation

Project description:Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determine global expression changes in the lung following radiation exposure. RNA was extracted from K-rasLA1 lungs from unirradiated control animals or those irradiated with a fractionated or acute dose of 1.0Gy 56Fe- particles 70 days post-irradiation when lungs are still histologically indistiguishable and only contain benign lesions.

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Expression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation

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mRNA expression signatures of human glioblastoma stem cell like cells after treatment with FG-3019, irradiation and FG-3019 + irradiation

Project description:To investigate effects on mRNA expression through treatment with FG-3019, irradiation and their combination to gain mechanistic hypotheses on the effects of these treatments on glioblastoma stem cell like cells which have been observed in vitro and in vivo. mRNA expression was measured 6 h after treatment with FG-3019, irradiation and their combination. 3 biological replicates were analyzed for each treatment condition (control, FG-3019, irratiation and FG-3019+irradiation)

2014-08-30 | E-GEOD-60921 | biostudies-arrayexpress

mRNA expression signatures of human glioblastoma stem cell like cells after treatment with FG-3019, irradiation and FG-3019 + irradiation

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Irradiation of healthy brain alters expression of genes involved in cell motility and invasiveness of glioblastoma

Project description:Traumatic brain injury is known to cause proliferation and migration of astrocytic and neuronal cells. To find out whether irradiation may influence migration of intracranial tumors, we performed expression profiling of orthotopically implanted glioblastomas following irradiation to the contralateral (non-diseased) hemisphere. Microarrays were used to identify differentially expressed genes associated with glioblastoma-malignancy in distinct tumor compartments following irradiation of brain tissue of contralateral (non-diseased) hemisphere. Differentially expressed genes were the object to functional network analysis with Ingenuity pathway analysis software

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Fractionated Proton Irradiation does not Impair Hippocampal Dependent Short Term or Spatial Memory in Female Mice

Project description:The environment outside the Earth’s protective magnetosphere is a much more threatening and complex space environment. The dominant causes for radiation exposure, solar particle events and galactic cosmic rays, contain high-energy protons. In space, astronauts need healthy and highly functioning cognitive abilities, of which the hippocampus plays a key role. Therefore, understanding the effects of 1H exposure on hippocampal-dependent cognition is vital for de-veloping mitigative strategies and protective countermeasures for future missions. To investi-gate these effects, we subjected 6-month-old female CD1 mice to 0.75 Gy fractionated 1H (250 MeV) whole-body irradiation at the NASA Space Radiation Laboratory. The cognitive perfor-mance of the mice was tested 3 months after irradiation using Y-maze and morris water maze tests. Both sham-irradiated and 1H-irradiated mice significantly preferred exploration of the novel arm compared to the familiar and start arms, indicating intact spatial and short-term memory. Both groups statistically spent more time in the target quadrant, indicating spatial memory retention. There were no significant differences in neurogenic and gliogenic cell counts after irradiation. In addition, proteomic analysis revealed no significant upregulation or down-regulation of proteins related to behavior, neurological disease, or neural morphology. Our data suggests 1H exposure does not impair hippocampal-dependent spatial or short-term memory in female mice.

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Gene expression profile of mouse Lewis lung carcinoma cell line treated with single or fractionated ionizing radiation doses

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2016-07-07 | GSE84108 | GEO

Gene expression profile of mouse Lewis lung carcinoma cell line treated with single or fractionated ionizing radiation doses

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