Fungi
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA419101 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Fungal ITS2-Inferred Rhizobiome Chestnut Breedinglines in Vallonia Nursery
| PRJNA432081 | ENA
Project description:ITS2 region of fungal species on amphibian skin swabs Raw sequence reads
| PRJNA429422 | ENA
Project description:Sequencing of ITS2 fungal datasets from soil
| PRJEB40328 | ENA
Project description:<p><strong>Background</strong></p><p>Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs targeting bacteria are therefore seen as an important risk factor for fungal infections and induced allergies. However, antibiotic effects on gut bacterial-fungal interactions, including disruption and resilience of fungal community compositions, were not investigated in humans. We analysed stool samples collected from 14 healthy human participants over three months following a 6-day antibiotic administration. We integrated data from shotgun metagenomics, metatranscriptomics, metabolomics, and fungal ITS2 sequencing. </p><p><strong>Results</strong></p><p>While the bacterial community recovered mostly over three months post treatment, the fungal community was shifted from mutualism at baseline to competition. Half of the bacterial-fungal interactions present before drug intervention had disappeared three months later. During treatment, fungal abundances were associated with the expression of bacterial genes with functions for cell growth and repair. By extending the metagenomic species approach, we revealed bacterial strains inhibiting the opportunistic fungal pathogen Candida albicans. We demonstrate in vitro how C. albicans pathogenicity and host cell damage might be controlled naturally in the human gut by bacterial metabolites such as propionate or 5-dodecenoate.</p><p><strong>Conclusions</strong></p><p>We demonstrate that antibacterial drugs have long-term influence on the human gut mycobiome. While bacterial communities recovered mostly 30-days post antibacterial treatment, the fungal community was shifted from mutualism towards competition.</p><p><br></p><p><strong>Linked data:</strong></p><p>Metagenomics has been submitted to NCBI SRA repository as projects PRJNA573821, PRJNA573905 and PRJNA579284.</p>
2020-09-28 | MTBLS1846 | MetaboLights
Project description:B. bassiana regulates transcriptional adaptation to host hemocoel, which is a determinant to the biocontrol potential of fungal entomopathogens. The global transcriptome related to fungal development in host was analyzed by using high throughput sequencing (RNA-Seq). Our transcriptional profiles revealed that majority of fungal genes are involved in fungal growth in host environmental, and are associated with various cellular processes.
2020-03-17 | GSE97042 | GEO
Project description:The effects of two years' winter warming on the overall fungal functional gene structure in Alaskan tundra soil were studies by the GeoChip 4.2 Resuts showed that two years' winter warming changed the overall fungal functional gene structure in Alaskan tundra soil.
2019-03-07 | GSE127899 | GEO