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Investigate A2M treatment in liver of mice

ABSTRACT: Investigate A2M treatment in liver of mice

OTHER RELATED OMICS DATASETS IN: GSE107195GSE107194

PROVIDER: PRJNA419257 | ENA |

REPOSITORIES: ENA

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Investigate A2M treatment in liver of mice

Project description:Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat’s cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumour development. Here we found that A2M modulates tumour cell adhesion, migration and growth by inhibition of tumour promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumour xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.

2018-01-30 | GSE107194 | GEO

Investigate A2M treatment on human prostate cancer and mouse liver

Project description:Investigate A2M treatment on human prostate cancer and mouse liver

| PRJNA419249 | ENA

Investigate A2M treatment on human prostate cancer xenograft in mice

Project description:Investigate A2M treatment on human prostate cancer xenograft in mice

| PRJNA418738 | ENA

Investigate A2M treatment on human prostate cancer xenograft in mice

Project description:Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat’s cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumor development. Here we found that A2M modulates tumor cell adhesion, migration and growth by inhibition of tumor promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumor xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumor cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumor promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.

2018-01-25 | GSE106989 | GEO

ATAC-seq of mice liver upon different diet treatment

Project description:ATAC-seq of mice liver upon different diet treatment

| PRJNA663444 | ENA

Gene expression profiling of liver from regulatar chow (RC) fed-mice, high fat diet (HFD)-fed mice with vehicle or nobiletin (NOB) treatment

Project description:Comparison of liver transcriptome between RC-fed mice, HFD-fed mice with vehicle or nobiletin treatment provides the possibility to identify the effects of nobiletin on gene expression altered by HFD relative to RC. We used Illumina microarrays to analyze liver transcriptome of different treatment groups following exposure to RC, HFD.Veh (denoted as the HFD group) and HFD.NOB (denoted as the NOB group). The microarray experiment was performed to investigate effects of HFD and NOB on mouse liver transcriptome. Liver tissues were collected at ZT2 and ZT14 (corresponding to 2 hours after light on and light off, respectively). The pooled RNA samples, 4 mice each group, were used for the microarray.

2016-03-03 | E-GEOD-78848 | biostudies-arrayexpress

ATAC-seq of mice liver upon different diet treatment

Project description:ATAC-seq was performed using mice liver from chow diet, western diet or high fat diet treatment.

2021-05-27 | GSE157907 | GEO

Liver samples of DO mice

Project description:Liver samples of DO mice

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Aldr KO mice in liver with Fenofibrate treatment

Project description:Transcriptomic characterization of ABCD2 KO mice to fibrate treatment in liver tissue, 3 months of age ABCD2 KO and age-matched WT mice were administered fenofibrate (100 mg/kg/day) for 14 days.

2014-04-01 | E-MTAB-2006 | biostudies-arrayexpress

Liver array following CMPF treatment

Project description:Liver array following CMPF treatment

| PRJNA417491 | ENA