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Epigenetic Effects of Maternal Obesity on Wharton's Jelly (WJ) Mesenchymal Stromal Cells (MSCs): Implications For Cellular Therapy.

ABSTRACT: Epigenetic Effects of Maternal Obesity on Wharton's Jelly (WJ) Mesenchymal Stromal Cells (MSCs): Implications For Cellular Therapy.

PROVIDER: PRJNA419325 | ENA |

REPOSITORIES: ENA

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Gene expression patterns of mesenchymal stem cells from bone marrow and Wharton's jelly of umbilical cord

Project description:Mesenchymal stem cells (MSCs) are promising tools for the treatment of diseases such as infarcted myocardia and strokes because of their ability to promote endogenous angiogenesis and neurogenesis via a variety of secreted factors. MSCs found in the Wharton's jelly of the human umbilical cord are easily obtained and are capable of transplantation without rejection. We isolated MSCs from WhartonM-bM-^@M-^Ys jelly and bone marrow (WJ-MSCs and BM-MSCs, respectively) and compared their transcriptional profiles. In this study, BM-MSCs and WJ-MSCs were isolated from 4 and 3 independent donors, respectively.

2013-09-30 | E-GEOD-48022 | biostudies-arrayexpress

Epigenetic Effects of Maternal Obesity on Wharton's Jelly (WJ) Mesenchymal Stromal Cells (MSCs): Implications For Cellular Therapy. (expression study)

Project description:Epigenetic Effects of Maternal Obesity on Wharton's Jelly (WJ) Mesenchymal Stromal Cells (MSCs): Implications For Cellular Therapy. (expression study)

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Gene expression patterns of mesenchymal stem cells from bone marrow and Wharton's jelly of umbilical cord

Project description:Mesenchymal stem cells (MSCs) are promising tools for the treatment of diseases such as infarcted myocardia and strokes because of their ability to promote endogenous angiogenesis and neurogenesis via a variety of secreted factors. MSCs found in the Wharton's jelly of the human umbilical cord are easily obtained and are capable of transplantation without rejection. We isolated MSCs from Wharton’s jelly and bone marrow (WJ-MSCs and BM-MSCs, respectively) and compared their transcriptional profiles.

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Epigenetic Effects of Maternal Obesity on Wharton's Jelly (WJ) Mesenchymal Stromal Cells (MSCs): Implications For Cellular Therapy. (expression study)

Project description:7 WJ-MSC lines from non-obese BMI <25 kg/m2 were compared with 7 WJ-MSC lines obese BMI >30 kg/m2. No template was used as a negative control Triplicates for each line were analyses for human whole-genome gene expression profile using HumanHT-12 v4.0 Expression BeadChip (Illumina).

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Epigenetic Effects of Maternal Obesity on Wharton's Jelly (WJ) Mesenchymal Stromal Cells (MSCs): Implications For Cellular Therapy. (methylation study)

Project description:7 WJ-MSC lines from non-obese BMI <25 kg/m2 were compared with 7 WJ-MSC lines obese BMI >30 kg/m2. No template was used as a negative control Triplicates for each line were analyses for epigenome-wide methylation (>480,000 CpG sites) using Infinium Human Methylation 450 BeadChip Kit (Illumina).

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miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells

Project description:Administration of mesenchymal stem cells (MSCs) has the potential to ameliorate degenerative disorders and to repair damaged tissues. The homing of transplanted MSCs to injured sites is a critical property of engraftment. Our aim was to identify microRNAs involved in controlling MSC proliferation and migration. MSCs can be isolated from bone marrow and umbilical cord Wharton's jelly (BM-MSCs and WJ-MSCs, respectively), and WJ-MSCs show poorer motility yet have a better amplification rate compared to BM-MSCs.

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miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells

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Comparison of human isogeneic Wharton’s Jelly MSCs and iPSC-derived MSCs responses to interferon-gamma (IFNG) stimulation

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Expression profiles of salivary gland MSC or wharton's jelly MSC, and their extracellular vesicles

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Extracellular Vesicles Derived from Wharton’s Jelly Mesenchymal Stem Cells Inhibit the Tumor Environment via the miR-125b/HIF-1a Signaling Pathway

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