Genomics

Dataset Information

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RNA-seq of tumor residing CD8+ T cells overexpressing Runx3


ABSTRACT: RNA-seq of tumor residing CD8+ T cells overexpressing Runx3

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA419738 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR6321774_1.fastq.gz Fastqsanger.gz
SRR6321774_2.fastq.gz Fastqsanger.gz
SRR6321775_1.fastq.gz Fastqsanger.gz
SRR6321775_2.fastq.gz Fastqsanger.gz
SRR6321776_1.fastq.gz Fastqsanger.gz
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Publications


Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune responses. However, the molecular signals that control TRM cell differentiation and homeostasis are not fully understood. Here we show that mouse TRM precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory cell populations at the levels of gene expression and chromatin accessibility. Using computati  ...[more]

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