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Plasma circRNA expression profile in systemic lupus erythematosus and its clinical significance

ABSTRACT: Plasma circRNA expression profile in systemic lupus erythematosus and its clinical significance

PROVIDER: PRJNA419822 | ENA |

REPOSITORIES: ENA

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Plasma circRNA expression profile in systemic lupus erythematosus and its clinical significance

Project description:Circular RNAs (circRNAs) are a novel class of non-coding RNA and stably conserved in mammalian cells. Although circRNAs have been widely reported in some diseases and tissues, the expression of circRNAs in systemic lupus erythematosus (SLE) have yet to be explored. To reveal the implications of circRNAs in SLE, we used Human circRNA Array v2.0 microarrays to measure the expression profiles of circRNAs in plasma of patients with SLE and healthy controls. A total of 4763 circRNAs were detected in plasma of SLE sample, and 112 circRNAs were identified to be differentially expressed in plasma of SLE patients as compared to healthy controls (fold change >1.5 and P < 0.05), including 53 up-regulated circRNAs and 59 down-regulated circRNAs. Hsa_circRNA_407176, hsa_circRNA_406567 and hsa_circRNA_001308 were established using Real-time quantitative PCR. These results showed abrrant expression profiles of circRNAs in T cells of SLE patients and revealed their potential role in SLE.

2020-11-27 | GSE107344 | GEO

Systemic Lupus Erythematosus patient blood with controls

Project description:The experiment consists of 31 Systemic Lupus Erythematosus patient blood samples and 29 healthy donor blood samples.

2018-03-21 | GSE112087 | GEO

Spatial transcriptomics of Cutaneous and Systemic Lupus Erythematosus skin

Project description:We performed spatial transcriptomics on a case series of different clinical subtypes of cutaneous lupus erythematosus including acute cutaneous lupus erythematosus (malar rash, systemic lupus erythematosus). Our goals were to (1) determine which differentially expressed genes (DEGs) could be attributed to specific cell populations in specific locations within the tissue, (2) determine if spatial transcriptomics could better distinguish between CLE clinical subtypes than bulk RNA approaches and (3) examine potential cell-cell communication pathways within the skin lesions.

2021-10-01 | GSE182825 | GEO

Human peripheral blood cells: systemic lupus erythematosus vs healthy individual.

Project description:Gene expression profiling of peripheral blood cells from patients with systemic lupus erythematosus (SLE) vs healthy individual (HI).

2010-10-01 | GSE20864 | GEO

DNA methylation in systemic lupus erythematosus patients

Project description:To screen specific DNA methylation markers in systemic lupus erythematosus (SLE) patient's blood DNA, whole-blood DNAs from 6 female SLE patients and 6 female controls were analyzed by methylation microarray.

2016-12-27 | GSE57869 | GEO

High-Density Lipoproteins - small RNA Signatures in Systemic Erythematosus Lupus.

Project description:Study of high-density lipoproteins using 6 human plasma samples. The study sought to find small RNA signatures in systemic erythematosus lupus.

2018-10-27 | GSE121865 | GEO

Human peripheral blood cells: systemic lupus erythematosus vs healthy individual.

Project description:Gene expression profiling of peripheral blood cells from patients with systemic lupus erythematosus (SLE) vs healthy individual (HI). Peripheral blood was obtained from patients with SLE (n=21) and HI (n=45). Blood samples from 45 HI are used as control.

2010-10-01 | E-GEOD-20864 | biostudies-arrayexpress

Systemic Lupus Erythematosus patient blood with controls

Project description:Systemic Lupus Erythematosus patient blood with controls

| PRJNA439269 | ENA

RNA-seq of peripheral blood mononuclear cell (PBMC) derived from normal healthy donors and systemic lupus erythematosus (SLE) patients

Project description:Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease. There is no cure for SLE. The mechanism involves an immune response by autoantibodies against a person's own tissues. However, the mechanism underlying imbalance of autoantibodies is not clear. In this experiment, peripheral blood was obtained from normal healthy donors and systemic lupus erythematosus (SLE) patients. Peripheral blood mononuclear cells (PBMC) were separated by Ficoll separation solution. Samples of four (total eight) donors were pooled and Samples of four (total eight) SLE patients were pooled. The aim was to characterize the mRNA profile of SLE patients compared to healthy donors and find the new target of diagnosis or treatment for SLE.

2020-08-14 | E-MTAB-7145 | biostudies-arrayexpress

lncRNA profiling in moDCs of systemic lupus erythematosus

Project description:Recent studies have shown that alterations in the function of dendritic cells (DCs) are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of DCs participating in SLE remains unclear. We profiled the lncRNAs of LPS-stimulated moDCs in SLE patients compared with healthy controls.

2018-07-19 | GSE89240 | GEO

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