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Gene expression profiling of HSCs treated with Eltrombopag

ABSTRACT: Gene expression profiling of HSCs treated with Eltrombopag

PROVIDER: PRJNA420062 | ENA |

REPOSITORIES: ENA

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Gene expression profiling of mouse HSCs treated with Eltrombopag

Project description:Eltrombopag, a small molecule thrombopoietin receptor (TPO-R) agonist and potent intracellular iron chelator, has shown remarkable efficacy to stimulate sustained multilineage hematopoiesis in patients with bone marrow failure syndromes, suggesting an effect at the most immature hematopoietic stem and multipotent progenitor level. While the functional and molecular effects of Eltrombopag on megakaryopoiesis have been carefully studied in the recent past, insights into its mechanistic impact on the earliest stages of hematopoiesis have been limited. Additionally, previous studies also revealed molecular pathway of Eltrombopag apart from stimulation of TPO signaling, detail characterization remains to be addressed. In this study, we investigated the effects of Eltrombopag, in comparison with TPO, on highly-purified primary hematopoietic stem cells (HSCs) from healthy human donors. The binding of Eltrombopag to TPO-R is species-specific to human and primate cells. we also utilized HSCs isolated mouse as separation-of-function models to directly assess the molecular effect of Eltrombopag on HSCs independent of TPOR stimulation.

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Gene expression profiling of human HSCs treated with Eltrombopag

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Gene expression profiling of human HSCs treated with Eltrombopag

Project description:Gene expression profiling of human HSCs treated with Eltrombopag

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Gene expression profiling of mouse HSCs treated with Eltrombopag

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RNA sequencing of Cryptococcus neoformans H99 treated with eltrombopag

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Identification of differentially expressed genes upon treatment with Eltrombopag in HL60 cells

Project description:Identification of differentially expressed genes upon treatment with Eltrombopag in HL60 cells. HL60 cells were untreated, or treated with 3ug/ml of Eltrombopag for 36 hrs in RPMI with 10% FBS HL60 cells were untreated, or treated with 3ug/ml of Eltrombopag for 36 hrs in RPMI with 10% FBS

2012-06-24 | E-GEOD-37580 | biostudies-arrayexpress

Gene expression profiling of HSCs treated with Eltrombopag

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-09-17 | GSE107430 | GEO

Identification of differentially expressed genes upon treatment with Eltrombopag in HL60 cells

2012-06-25 | GSE37580 | GEO

RNA sequencing of Cryptococcus neoformans H99 treated with eltrombopag

Project description:RNA sequencing of Cryptococcus neoformans H99 treated with eltrombopag

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Gene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL

Project description:We have developed a new conditional transgenic mouse showing that MLL-ENL, at an endogenous-like expression level, induces leukemic transformation selectively in LT-HSCs. To investigate the molecular mechanism of leukemic transformation in LT-HSCs conditionally expressing MLL-ENL, we preliminarily performed comprehensive gene expression profiling of CreER-transduced LT-HSCs and ST-HSCs using cDNA microarray analysis.

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