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Gene expression in islets from control (WT) or transgenic (MYC) animals

ABSTRACT: Gene expression in islets from control (WT) or transgenic (MYC) animals

PROVIDER: PRJNA420848 | ENA |

REPOSITORIES: ENA

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Gene expression in islets from control (WT) or transgenic (MYC) animals

Project description:We report changes in gene expression in mouse islets that express c-MYC in pancreatic beta cells as compared to control cells that lack such ectopic expression. The goal of the study is to identify the MYC-dependent changes that occur in beta cells that affect cellular fate and function.

2018-01-01 | GSE107617 | GEO

Expression data from transgenic Aire expressing pancreatic islets

Project description:The aim of this study was to determine the effect of transgenic Aire expression on the transcriptional profile of a tissue that normally does not express Aire: pancreatic islets. The transcriptional profile of transgenic RIP-Aire27 islets was compared to non-transgenic littermate islets as well as to archival NOD thymic medullary epithelial cells (MEC) data. All data were from non-obese diabetic (NOD) mice Keywords: RIP-Aire transgenic vs non-transgenic comparison

2008-08-20 | GSE12073 | GEO

Transcription profiling of mouse transgenic for Aire expressing pancreatic islets

Project description:The aim of this study was to determine the effect of transgenic Aire expression on the transcriptional profile of a tissue that normally does not express Aire: pancreatic islets. The transcriptional profile of transgenic RIP-Aire27 islets was compared to non-transgenic littermate islets as well as to archival NOD thymic medullary epithelial cells (MEC) data. All data were from non-obese diabetic (NOD) mice Experiment Overall Design: 3-wk-old individual male RIP-Aire27 or non-transgenic littermates islets were isolated by gradient purification followed by hanpicking under a microscope for subsequent RNA purification, labeling and hybridization to Affymetrix arrays.

2008-10-25 | E-GEOD-12073 | biostudies-arrayexpress

Astrocyte mRNA expression - comparison of wild type animals to CETP transgenic animals

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RNA-seq of primary islets in WT and Brsk2 transgenic mice

Project description:RNA-seq of primary islets in WT and Brsk2 transgenic mice

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Transgenic MYC OFF timecourse in murine MYC-dependent cell line

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Expression of genes in Runx2/Myc transgenic mouse thymus compared to control

Project description:Retroviral insertional mutagenesis (RIM) is a powerful tool in cancer genomics. Transgenic mice expressing two potent collaborating oncogenes in the germline, Myc and Runx2, develop rapid onset tumours that can be accelerated and rendered polyclonal by neonatal infection with MoMLV. Deep sequencing of lymphomas from infected Runx2/Myc mice revealed a network of progression genes. Transcriptional analysis of basal expression levels in transgenic cells showed that the progression network showed strong evidence of clonal selection beyond gene expression level. We examined the gene expression profile of triplicate 10 day old thymus from CD2-Myc/CD2-Runx2 and C57/CBA mice to examine early gene changes in comparison to RIM targets in end stage tumours. We found no significant relationship between basal expression in the transgenic system and genes that were targets for retroviral integration.

2016-04-14 | E-GEOD-80254 | biostudies-arrayexpress

Expression of genes in Runx2/Myc transgenic mouse thymus compared to control

2016-04-14 | GSE80254 | GEO

Astrocyte mRNA expression - comparison of wild type animals to CETP transgenic animals

Project description:CETP transfers lipids and cholesteryl esters between lipoproteins. This leads to elevated LDL-cholesterol levels. We found elevated cholesterol levels in the brains CETP transgenic animals. We wanted to test whether this is due to increased cholesterol synthesis by astrocytes 2 animals that were genotyped as wild type showed CETP transcription in our RT-qPCR (WT_1 & WT_5) and were excluded

2018-03-01 | GSE111242 | GEO

Transcription Profiling of Lung Adenocarcinomas of c-Myc-Transgenic Mice

Project description:The transcriptional regulator c-Myc is the most frequently deregulated oncogene in human tumors. Targeted overexpression of this gene in mice results in distinct types of lung adenocarcinomas. By using microarray technology, alterations in the expression of genes were captured based on a female transgenic mouse model in which, indeed, c-Myc overexpression in alveolar epithelium results in the development of bronchiolo-alveolar carcinoma (BAC) and papillary adenocarcinoma (PLAC). In this study, we analyzed exclusively the promoters of induced genes by different in silico methods in order to elucidate the c-Myc transcriptional regulatory network. Keywords: c-myc transgenic versus non-transgenic

2008-05-31 | GSE10954 | GEO

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