Genomics

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Transcriptomic analysis of glioblastoma cells bearing different IRE1a mutants


ABSTRACT: Transcriptomic analysis of glioblastoma cells bearing different IRE1a mutants

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA421725 | ENA |

REPOSITORIES: ENA

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Publications


Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical role in cancer development. This concept is valid in glioblastoma multiform (GBM), the most lethal primary brain cancer with no effective treatment. We previously demonstrated that the ER stress sensor IRE1α (referred to as IRE1) contributes to GBM progression, through XBP1 mRN  ...[more]

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