Genomics

Dataset Information

118

De novo formation of a functional biliary system by TGFβ-mediated hepatocyte transdifferentiation


ABSTRACT: De novo formation of a functional biliary system by TGFβ-mediated hepatocyte transdifferentiation

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA423097 | ENA |

REPOSITORIES: ENA

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Publications


Transdifferentiation is a complete and stable change in cell identity that serves as an alternative to stem-cell-mediated organ regeneration. In adult mammals, findings of transdifferentiation have been limited to the replenishment of cells lost from preexisting structures, in the presence of a fully developed scaffold and niche1. Here we show that transdifferentiation of hepatocytes in the mouse liver can build a structure that failed to form in development-the biliary system in a mouse model t  ...[more]

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