Genomics

Dataset Information

118

De novo formation of a functional biliary system by TGFβ-mediated hepatocyte transdifferentiation


ABSTRACT: De novo formation of a functional biliary system by TGFβ-mediated hepatocyte transdifferentiation

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA423097 | ENA |

REPOSITORIES: ENA

altmetric image

Publications


Transdifferentiation is a complete and stable change in cell identity that serves as an alternative to stem-cell-mediated organ regeneration. In adult mammals, findings of transdifferentiation have been limited to the replenishment of cells lost from preexisting structures, in the presence of a fully developed scaffold and niche1. Here we show that transdifferentiation of hepatocytes in the mouse liver can build a structure that failed to form in development-the biliary system in a mouse model t  ...[more]

Similar Datasets

| GSE108315 | GEO
2012-03-01 | E-GEOD-34166 | ArrayExpress
| PRJNA80809 | ENA
2019-04-30 | E-MTAB-7114 | ArrayExpress
2020-05-08 | E-MTAB-9010 | ArrayExpress
2016-07-03 | E-GEOD-51389 | ArrayExpress
2009-04-03 | GSE14491 | GEO
2015-12-15 | E-GEOD-73095 | ArrayExpress
2012-02-01 | E-GEOD-30515 | ArrayExpress
2015-03-01 | E-GEOD-59856 | ArrayExpress