Project description:Single cell transcriptome profiling of the bone marrow niche at steady state and under stress conditions (validation experiment)

| PRJNA507444 | ENA

3D models of the hematopoietic stem cell niche under steady-state and active conditions.

Project description: Not available

| S-EPMC5496931 | biostudies-literature

Extracellular vesicles shed by follicular lymphoma B cells promote the polarization of bone marrow stromal cell niche

Project description:Characterisation of the extracellular vesicles shed by follicular lymphoma B cells that induce the polarization of bone marrow stroma cell toward a pro-tumoral niche.

2021-02-08 | PXD023749 | Pride

Inflammation of the Aged Bone Marrow Niche Drives Blood Aging

Project description:Hematopoietic aging is defined by a loss of regenerative capacity and skewed differentiation from hematopoietic stem cells (HSC) leading to dysfunctional blood production. Signals from the bone marrow (BM) microenvironment dynamically tailor hematopoiesis, but the effect of aging on the niche and the contribution of the aging niche to blood aging still remains unclear. Here, we show the development of an inflammatory milieu in the aged marrow cavity, which drives both niche and hematopoietic system remodeling. We find decreased numbers and functionality of osteogenic endosteal mesenchymal stromal cells (MSC), expansion of pro-inflammatory perisinusoidal MSCs, and deterioration of the central marrow sinusoidal endothelium, which together create a self-reinforcing inflamed BM milieu. Single cell molecular mapping of old niche cells further confirms disruption of cell identities and enrichment of inflammatory response genes. Inflammation, in turn, drives chronic activation of emergency myelopoiesis pathways in old HSCs and multipotent progenitors, which promotes myeloid differentiation at the expense of lymphoid and erythroid commitment, and hinders hematopoietic regeneration. Remarkably, both defective hematopoietic regeneration, niche deterioration and HSC aging can be improved by blocking inflammatory IL-1 signaling. Our results indicate that targeting the pro-inflammatory niche milieu can be instrumental in restoring blood production during aging.

2022-11-02 | GSE168613 | GEO

Single cell RNA-seq analysis for spleen tissue under steady state, phenohydrazine (PHZ) and bleeding treatment.

Project description:Single cell RNA-seq analysis for spleen tissue isolated from mice under steady state, and subjected to phenohydrazine (PHZ) and bleeding treatment respectively. Single cell RNA-seq analysis for bone marrow cells isolated from mice under steady state.

2024-02-19 | GSE230331 | GEO

Kinetic barriers under steady-state conditions.

Project description: Not available

| S-EPMC1132718 | biostudies-other

Transcription profiling of cat CrFK cells grown under steady state conditions

Project description:Characterization of CrFK Cells Grown Under Steady State Conditions:<br> <br> To identify non-specific or inconsistent hybridizations, 4 arrays were hybridized to cDNA from different populations of uninfected CrFK cells, and 2 arrays to cells exposed to "spent" (culture media isolated from cells grown normally in culture for 3-7 days) culture media. Data from uninfected cells were analyzed individually, and in combination with data from media-treated cells, as described above.

2004-11-30 | E-MEXP-205 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data