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Expression data from SUM149 inflammatory breast cancer cells cultured in monolayer or Matrigel

ABSTRACT: Expression data from SUM149 inflammatory breast cancer cells cultured in monolayer or Matrigel

PROVIDER: PRJNA430729 | ENA |

REPOSITORIES: ENA

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Expression data from SUM149 inflammatory breast cancer cells cultured in monolayer or Matrigel

Project description:Inflammatory breast cancer (IBC) is a rare type of breast cancer but accounts for up to 10% of breast cancer-related deaths. Plasticity between epithelial and mesenchymal feature is reported to be crucial in metastasis of IBC. Using Matigel culture, we induced epithelial to mesenchymal transition (EMT) in epithelial-like SUM149 IBC cells and identified overexpressed genes in this EMT process.

2018-04-01 | GSE109396 | GEO

Expression data from isolated endothelial cells from glioblastoma and normal brain cultured as monolayer on gelatin and on Matrigel

Project description:Expression data from isolated endothelial cells from glioblastoma and normal brain cultured as monolayer on gelatin and on Matrigel

| PRJNA573737 | ENA

Transcription profiling of human liver LI90 cells cultured on Matrigel

Project description:Transcriptional analysis of human hepatic stellate cells cultured on Matrigel.

2010-03-01 | E-MEXP-2582 | biostudies-arrayexpress

Transcription profiling of human LX-2 cells cultured on Matrigel

Project description:we performed transcriptional analysis of the human hepatic stellate cell line, LX-2, cultured on Matrigel.

2010-10-01 | E-MEXP-2584 | biostudies-arrayexpress

Transcriptomes of high-grade serous ovarian cancer cell lines cultured in monolayer and in spheroids.

Project description:HGSOC cancer cell lines OvCAR3 and G164 were cultured in monolayer and spheroids and subjected to RNA-sequencing.

2024-05-02 | GSE235099 | GEO

HUVEC with/without VEGF-A treatment in 3D matrigel or 2D monoculture

Project description:To profile changes in gene expression in human endothelial cells in response to VEGF-A165 and phenotypic changes during vascular network formation in vitro 16 samples of human umbilical vein endothelial cells were analysized, four distinct biological samples were used in each condition. The four conditions included: VEGF treatment in Matrigel culture, Mock treatment in Matrigel culture, VEGF treatment in 2D monolayer, and mock treatment in 2D monolayer.

2015-06-30 | E-GEOD-53550 | biostudies-arrayexpress

Tissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoids

Project description:To determine the performance of the decellularized GI tissue ECM hydrogel, we analyzed differences in mRNA expression levels in native gastric tissues, gastric organoids cultured in Matrigel and those cultured in decellularized gastric ECM hydrogel. We also compared mRNA expression levels of native small intestinal tissues, small intestinal organoids grown in Matrigel and those grown in decellularized intestinal ECM hydrogel.

2022-01-30 | GSE165309 | GEO

Whole transcriptome data of human liver organoids cultured in Matrigel and polyisocyanopeptides-based hydrogel

Project description:End-stage liver diseases are an increasing health burden and liver transplantations are currently the only curative treatment option. Due to a lack of donor livers, alternative treatments are urgently needed. Human liver organoids are very promising for regenerative medicine, however, organoids are currently cultured in Matrigel, which is extracted from the extracellular matrix of the Engelbreth-Holm-Swarm mouse sarcoma. Matrigel is poorly defined, suffers from high batch-to-batch variability and is of murine origin, which limits clinical application of organoids. Here, a novel hydrogel based on polyisocyanopeptides (PIC) and laminin-111 is described for human liver organoid culture. PIC is a synthetic hydrogel with thermodynamic properties, making it easy to handle and very attractive for clinical applications. Organoids in an optimized PIC hydrogel proliferate at rates comparable to Matrigel; proliferation rates are stiffness-dependent, with lower stiffnesses being optimal for organoid proliferation. Moreover, organoids can be efficiently differentiated towards hepatocyte-like cells with key liver functions. This proliferation and differentiation potential can be maintained over at least 16 passages. Our results indicate that PIC is a promising material for human liver organoid culture and has the potential to be used in a variety of clinical applications including cell therapy and tissue engineering.

2020-12-23 | GSE143223 | GEO

Expression data of MB114 Endothelial cells during in vitro angiogenesis on Matrigel

Project description:MB114 cells cultured on Matrigel for 1, 5, 15, 25 hours Keywords: time course experiment

2007-05-20 | GSE7507 | GEO

Gene expression profiles of mouse colonic epithelial monolayer cultured in air-liquid interface

Project description:The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. Our understanding of how this process occurs is limited by a lack of in vitro models that recapitulate key aspects of in vivo responses. We established a long-term, self-organizing 2D epithelial monolayer system to model the cyclic nature of epithelial alterations during injury-repair. Through RNA-seq analysis, we seek to evaluate the transcriptomic profiles of the cultured epithelial cells under select phases of “homeostasis-injury-repair” in vitro.

2019-12-29 | GSE127172 | GEO

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