Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Transgenerational Effects of Prenatal Synthetic Glucocorticoids on the Hippocampus Cortex

ABSTRACT: The Transgenerational Effects of Prenatal Synthetic Glucocorticoids on the Hippocampus Cortex

PROVIDER: PRJNA431992 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The Transgenerational Effects of Prenatal Synthetic Glucocorticoids on the Prefrontal Cortex

Project description:The Transgenerational Effects of Prenatal Synthetic Glucocorticoids on the Prefrontal Cortex

| PRJNA420037 | ENA

The Transgenerational Effects of Prenatal Synthetic Glucocorticoids on the Hippocampus Cortex

Project description:First generation animals (F1) were exposed to multiple courses of synthetic glucocorticoids in utero. Animals were then bred to produce second (F2) and third (F3) generation offspring. These animals underwent behavioural assessmenets before sacrifice. In this experiment the prefrontal cortex for F1, F2, and F3 female animals, as well as F1 males (Control and sGC) have been extracted via micro-punch and RNA has been extracted.

2020-04-14 | GSE109765 | GEO

DNA methylome signatures of prenatal exposure to synthetic glucocorticoids in hippocampus and peripheral whole blood of female guinea pigs in early life

Project description:We examined the hypothesis that prenatal synthetic glucocorticoids (sGC) administration alters DNA methylation signatures in Guinea pig offspring hippocampus and whole blood. Guinea pigs were treated with sGC or saline in late gestation. Genome-wide modifications of DNA methylation were analyzed using reduced representation bisulfite sequencing in juvenile female offspring.

2020-12-18 | GSE163447 | GEO

The Transgenerational Effects of Prenatal Synthetic Glucocorticoids on the Prefrontal Cortex

Project description:First generation animals (F1) were exposed to multiple courses of synthetic glucocorticoids in utero. Animals were then bred to produce second (F2) and third (F3) generation offspring. These animals underwent behavioural assessmenets before sacrifice. In this experiment the prefrontal cortex for F1, F2, and F3 female animals, as well as F1 males (Beta and Control) have been extracted via micro-punch and RNA has been extracted.

2019-02-05 | GSE107415 | GEO

The Transgenerational Effects of Prenatal Synthetic Glucocorticoids

Project description:First generation animals (F1) were exposed to multiple courses of synthetic glucocorticoids in utero. Animals were then bred to produce second (F2) and third (F3) generation offspring. These animals underwent behavioural assessmenets before sacrifice. In this experiment the paraventricular nucleus of the hypothalamus fo F1, F2, and F3 female anmials (Beta and Control) have been extracted via micro-punch and RNA has been extracted.

2017-11-01 | GSE85822 | GEO

Cavia porcellus

Project description:The Transgenerational Effects of Prenatal Synthetic Glucocorticoids

| PRJNA339489 | ENA

DNA methylome signatures of prenatal exposure to synthetic glucocorticoids in hippocampus and peripheral whole blood of female guinea pigs in early life

Project description:DNA methylome signatures of prenatal exposure to synthetic glucocorticoids in hippocampus and peripheral whole blood of female guinea pigs in early life

| PRJNA686115 | ENA

Expression data from adult mouse Prefrontal Cortex following prenatal infection

Project description:Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the prefrontal cortex of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection. We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy C57BL/6 mice were treated with the synthetic viral mimetic poly(I:C) (5 mg/kg, i.v.) or control (saline, i.v.) solution on gestation day 17. Offspring were subjected to cognitive and behavioral testing in adulthood, and then whole genome gene expression analysis with Affymetrix Microarray and subsequent q-PCR validation were performed on the prefrontal Cortex.

2016-03-01 | E-GEOD-77972 | biostudies-arrayexpress

Gene expression data from the hippocampus of rats with prenatal valproic acid exposure

Project description:In this study, we explored molecular alterations in the hippocampus of prenatal valproic acid (VPA)-exposed rats as a model of autism spectrum disorders (ASD). In addition, we assessed effects of chronic administration of intranasal oxytocin, a promising peptide for ASD treatment. Comparative analyses revealed that prenatal VPA exposure altered gene expression, a part of which is involved in key features including memory, developmental process, and epilepsy. Oxytocin partly improved these gene expression, which were predicted to interact with those involved in social behaviors and hippocampal-dependent memory. The present study documented molecular profiling in the hippocampus related to ASD and improvement by chronic treatment of oxytocin.

2022-02-12 | GSE196500 | GEO

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome

Project description:Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome

| PRJNA549944 | ENA