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SuperSeries: An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray


ABSTRACT: SuperSeries: An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray

PROVIDER: PRJNA433981 | ENA |

REPOSITORIES: ENA

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An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray.

Salas Lucas A LA   Koestler Devin C DC   Butler Rondi A RA   Hansen Helen M HM   Wiencke John K JK   Kelsey Karl T KT   Christensen Brock C BC  

Genome biology 20180529 1


Genome-wide methylation arrays are powerful tools for assessing cell composition of complex mixtures. We compare three approaches to select reference libraries for deconvoluting neutrophil, monocyte, B-lymphocyte, natural killer, and CD4+ and CD8+ T-cell fractions based on blood-derived DNA methylation signatures assayed using the Illumina HumanMethylationEPIC array. The IDOL algorithm identifies a library of 450 CpGs, resulting in an average R<sup>2</sup> = 99.2 across cell types when applied t  ...[more]

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