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Glucagon contributes to liver zonation in mice [Gcg KO]

ABSTRACT: Glucagon contributes to liver zonation in mice [Gcg KO]

PROVIDER: PRJNA434234 | ENA |

REPOSITORIES: ENA

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Glucagon contributes to liver zonation in mice [Gcg KO]

Project description:Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal function. Wnt/beta-catenin signaling controls metabolic zonation by activating genes in the perivenous hepatocytes, while suppressing genes in the periportal counterparts. We now demonstrate that glucagon opposes the actions of Wnt/beta-catenin signaling on gene expression and metabolic zonation pattern. The effects were more pronounced in the periportal hepatocytes where 28% of all genes were activated by glucagon and inhibited by Wnt/beta-catenin. The glucagon and Wnt/beta-catenin receptors and their signaling pathways are uniformly distributed in periportal and perivenous hepatocytes and the expression is not regulated by the opposing signal. Collectively, our results show that glucagon controls gene expression and metabolic zonation in the liver through a counter play with the Wnt/beta-catenin signaling pathway.

2018-03-01 | GSE110672 | GEO

Glucagon contributes to liver zonation in mice

Project description:Glucagon contributes to liver zonation in mice

| PRJNA434226 | ENA

Glucagon contributes to liver zonation in mice [Gcg infusion]

2018-03-01 | GSE110673 | GEO

Glucagon contributes to liver zonation in mice [Gcg infusion]

Project description:Glucagon contributes to liver zonation in mice [Gcg infusion]

| PRJNA434235 | ENA

Glucagon contributes to liver zonation.

Project description: Not available

| S-EPMC5924920 | biostudies-literature

Glucagon receptor deficient liver during postnatal development

Project description:Glucagon receptor deficient liver during postnatal development: fig S5a-S5c in Solloway et al. livers from ko and wt GCGR mice at various developmental stages

2015-06-02 | GSE68141 | GEO

Glucagon receptor signaling in GCGR KO mice

Project description:GCGR wt and ko mice Glucagon receptor signaling in GCGR KO mice: fig 2a in Solloway et al.

2015-06-02 | GSE68143 | GEO

Glucagon contributes to liver zonation in mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-03-01 | GSE110674 | GEO

RNAseq liver Glucagon+T3

Project description:21 samples of liver RNA coming from mice treated with glucagon (Gluc), thyroid hormone (T3), both, or the conjugated compound (Cp). Each sample comes from a single mice.

2016-09-28 | GSE85793 | GEO

Glucagon receptor blocked liver gene signature

Project description:Liver RNA-seq in lean or diet-induced obese mice administered with glucagon receptor blocking antibody

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