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Single cell transcriptomic analysis (InDrops) of FoxP3+ regulatory CD4+ T cells isolated from the spleen and visceral adipose tissue of wild-type and VAT-TCR transgenic mice

ABSTRACT: Single cell transcriptomic analysis (InDrops) of FoxP3+ regulatory CD4+ T cells isolated from the spleen and visceral adipose tissue of wild-type and VAT-TCR transgenic mice

OTHER RELATED OMICS DATASETS IN: GSE111070GSE109742GSE110547

PROVIDER: PRJNA434298 | ENA |

REPOSITORIES: ENA

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Single cell transcriptomic analysis (InDrops) of FoxP3+ regulatory CD4+ T cells isolated from the spleen and visceral adipose tissue of wild-type and VAT-TCR transgenic mice

Project description:Single cell transcriptomic analysis (InDrops) of FoxP3+ regulatory CD4+ T cells isolated from the spleen and visceral adipose tissue of wild-type and VAT-TCR transgenic mice

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Single cell transcriptomic analysis (InDrops) of mouse FoxP3- CD4+ Tconv cells and FoxP3+ regulatory CD4+ T cells isolated from spleen and visceral adipose tissue

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Project description:We reported transcriptional characterization of Treg and Tconv cells from thymic, splenic, and visceral adipose tissue (VAT) of vTreg53 TCR transgenic mice and control littermates. We examined the effect of Foxp3 on splenic and VAT CD4+ T cell transcriptome. We profiled gene expression in a novel PPARg+ splenic Treg population. We uncovered that the characteristic phenotype of VAT Treg cells was acquired in two stages.

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Single cell transcriptomic analysis (InDrops) of mouse FoxP3- CD4+ Tconv cells and FoxP3+ regulatory CD4+ T cells isolated from spleen and visceral adipose tissue

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