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Resident macrophage enhances an autoimmune lesion in Sjögren's syndrome

ABSTRACT: Resident macrophage enhances an autoimmune lesion in Sjögren's syndrome

PROVIDER: PRJNA434644 | ENA |

REPOSITORIES: ENA

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Resident macrophage enhances an autoimmune lesion in Sjögren's syndrome

Project description:Macrophages are critical regulators of immune responses, and link innate immunity to acquired immunity. The precise mechanism of the pathogenesis of autoimmune diseases through tissue-resident macrophage is unclear. The role of the tissue-resident macrophages in the onset or development of autoimmunity was investigated using a murine model for Sjögren’s syndrome.

2018-02-21 | GSE110816 | GEO

PBMCs from patients with Sjögren's syndrome and healthy controls

Project description:Sjögren's syndrome is an autoimmune disease manifesting primarily as dryness of eyes and mouth. In this study, we compared gene expression in PBMCs between age- and gender-matched patients with Sjögren's syndrome (diagnosed by ACR criteria) and healthy controls. Cells were collected in heparinized tubes and PBMCs were prepared using Ficoll.

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Punctual ablation of Foxp3+ T cells unleashes an autoimmune lesion

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2009-10-15 | E-GEOD-18136 | biostudies-arrayexpress

Punctual ablation of Foxp3+ T cells unleashes an autoimmune lesion

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Whole-Blood gene expression profiling in primary Sjögren's Syndrome and healthy controls

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Hypomethylation mediates genetic association with the major histocompatibility complex genes in Sjögren's syndrome

Project description:A causal mediation analysis of DNA methylation as a mediator of nearby genetic association with Sjögren's syndrome using data collected from 131 female members of the Sjögren's International Collaborative Clinical Alliance registry, comprising of 64 Sjögren's syndrome cases and 67 non-cases.

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Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome.

Project description:Genome wide DNA methylation profiling of human labial salivary gland (LSG) biopsy samples obtained from 28 female members of the Sjögren's International Collaborative Clinical Alliance (SICCA) Registry. The Illumina HumanMethylation450 BeadChip platform was used to obtain DNA methylation profiles across more than 450,000 highly informative CpG sites. Samples included 15 non-case glands, and 13 glands from patients with Sjögren's Syndrome.

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Development of gene expression signatures of liver in a primary Sjögren's syndrome mouse model

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Lesion Segregation

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Transcriptome data of B cells in patients with primary Sjögren's syndrome

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2019-09-03 | GSE135809 | GEO

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