Resident macrophage enhances an autoimmune lesion in Sjögren's syndrome
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PROVIDER: PRJNA434644 | ENA |
REPOSITORIES: ENA
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CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome.
Ushio Aya A Arakaki Rieko R Otsuka Kunihiro K Yamada Akiko A Tsunematsu Takaaki T Kudo Yasusei Y Aota Keiko K Azuma Masayuki M Ishimaru Naozumi N
Frontiers in immunology 20181108
Macrophages (MΦs) are critical regulators of immune response and serve as a link between innate and acquired immunity. The precise mechanism of involvement of tissue-resident MΦs in the pathogenesis of autoimmune diseases is not clear. Here, using a murine model for Sjögren's syndrome (SS), we investigated the role of tissue-resident MΦs in the onset and development of autoimmunity. Two unique populations of CD11b<sup>high</sup> and CD11b<sup>low</sup> resident MΦs were observed in the target ti ...[more]
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