Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression profile of whole murine lung adenocarcinomas with or without overexpression of Snail

ABSTRACT: Expression profile of whole murine lung adenocarcinomas with or without overexpression of Snail

PROVIDER: PRJNA434800 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Expression profile of whole murine lung adenocarcinomas with or without overexpression of Snail

Project description:We used microarrays to study the changes in the transcriptional profile upon Snail overexpression in murine lung adenocarcinomas

2018-08-03 | GSE110871 | GEO

Expression profile of whole murine lung adenocarcinomas with or without knockdown of Snail

Project description:We used microarrays to study the changes in the transcriptional profile upon Snail knockdown in murine lung adenocarcinomas

2018-08-03 | GSE110870 | GEO

Expression profile of whole murine lung adenocarcinomas with or without Snail

Project description:Expression profile of whole murine lung adenocarcinomas with or without Snail

| PRJNA434797 | ENA

Expression profile of whole murine lung adenocarcinomas with or without knockdown of Snail

Project description:Expression profile of whole murine lung adenocarcinomas with or without knockdown of Snail

| PRJNA434799 | ENA

Expression profile of whole murine lung adenocarcinomas with or without Snail

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-08-03 | GSE110910 | GEO

Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer

Project description:Epithelial-mesenchymal transition (EMT) is in the highlights as a significant role in tumor progression and invasion. Snail was known as the one of regulators of EMT in various malignant tumors. The aim of this study was to investigate the effect of Snail on invasiveness/migratory ability of gastric cancer cell lines and clinicopathological and prognostic significance of Snail over-expression using immunohistochemistry in tissue microarray of 314 gastric adenocarcinomas (GC). Differential gene expression in Snail over-expressed GC was investigated using cDNA microarray analysis. Silencing of Snail by ShRNA induced decreased of invasion, migration of gastric cancer cell lines. In contrast, over-expression of Snail induced increased invasiveness and migratory ability of gastric cancer cell lines in accordance increase of VEGF and MMP11. Furthermore, the over-expression of Snail (≥75% nuclear staining of Snail) was significantly associated with tumor progression (p<0.0001), lymph node metastases (p=0.002), lymphovascular invasion (p=0.002), and perineural invasion (p=0.002) in 314 GC patient. Snail over-expression was also associated with poor prognosis (shorter survival) in GC patients (p=0.023). cDNA microarray revealed 213 differential expressed genes in Snail over-expressed GC tissues, including genes related to metastasis, invasion. Based on above results, it was suggested that Snail plays a significant role in invasiveness/migratory ability of GCs. In addition, Snail might be used to predictive biomarker for evaluation of prognosis or aggressiveness in GCs.

2012-05-18 | GSE38024 | GEO

Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer

Project description:Epithelial-mesenchymal transition (EMT) is in the highlights as a significant role in tumor progression and invasion. Snail was known as the one of regulators of EMT in various malignant tumors. The aim of this study was to investigate the effect of Snail on invasiveness/migratory ability of gastric cancer cell lines and clinicopathological and prognostic significance of Snail over-expression using immunohistochemistry in tissue microarray of 314 gastric adenocarcinomas (GC). Differential gene expression in Snail over-expressed GC was investigated using cDNA microarray analysis. Silencing of Snail by ShRNA induced decreased of invasion, migration of gastric cancer cell lines. In contrast, over-expression of Snail induced increased invasiveness and migratory ability of gastric cancer cell lines in accordance increase of VEGF and MMP11. Furthermore, the over-expression of Snail (?75% nuclear staining of Snail) was significantly associated with tumor progression (p<0.0001), lymph node metastases (p=0.002), lymphovascular invasion (p=0.002), and perineural invasion (p=0.002) in 314 GC patient. Snail over-expression was also associated with poor prognosis (shorter survival) in GC patients (p=0.023). cDNA microarray revealed 213 differential expressed genes in Snail over-expressed GC tissues, including genes related to metastasis, invasion. Based on above results, it was suggested that Snail plays a significant role in invasiveness/migratory ability of GCs. In addition, Snail might be used to predictive biomarker for evaluation of prognosis or aggressiveness in GCs. 48 primary gastric adenocarcinoma fresh frozen tissues were used for microarray. All the tissues were obtained after curative resection after pathologic confirm at Pusan National University Hospital (PNUH, Busan, Korea) and Cheonnam University Hospital (CNUH, Cheonnam, Korea). Microarray experiment and data analysis were done at Cancer research institute, PNUH, Busan, Korea.

2012-05-17 | E-GEOD-38024 | biostudies-arrayexpress

MicroRNA response to Snail overexpression in lung cancer cell lines

Project description:Analysis of four lung cancer cell lines transfected with a vector expressing the transcriptional repressor Snail versus a vector control. Aberrant Snail expression is known to induce an EMT program in lung cancers. Four lung cancer cell lines (H292, H358, H441, H1437) with stable overexpression of the human SNAI1 gene and vector expressing controls were collected at equal confluency with the miRNeasy Mini kit (Qiagen). One microgram of total RNA was labeled using miRCURY LNA™ microRNA Array Power Labeling kit by the UCLA Clinical Microarray Core. The labeled miRNAs were hybridized to Exiqon miRCURY LNA microRNA Array-6th Generation according to the manufacturer’s instructions. This array includes 927/648/351 human/mouse/rat miRNAs as well as 438 miRPlus miRNAs. The miRNA array slides were scanned using Axon GenePix 4000B scanner (Axon Instruments, Foster City, CA) and processed by using the GenePix Pro 6.0 software (Axon Instruments). The raw data were normalized by using a combination of housekeeping miRNA, spike-in miRNA and invariant endogenous miRNAs.

2013-07-17 | E-GEOD-48922 | biostudies-arrayexpress

MicroRNA response to Snail overexpression in lung cancer cell lines

2013-07-17 | GSE48922 | GEO

Microarray to study the effects of Snail overexpression in Glioblastoma cells.

Project description:Snail1 is a transcription factor known to promote the epithelial to mesenchymal transition process and stemness. We have previously described that in Glioblastoma BMP7 promotes glioblastoma initiating cells (GICs) to differentiate towards the astrocytic lineage and to lose their self-renewal capacity in a Snail-dependent manner. In order to elucidate how Snail promotes GIC differentiation, we decided to stably overexpress Snail in the U2987 glioblastoma cells. To understand which genes are regulated by Snail we performed a microarray screen with the Affymetrix U133plus2 platform and total RNA from U2987MG cells stably expressing Snail (U2987MG-Snail cells; clones F and G) versus control cells (clones A and B), two biological replicates per condition.

2018-01-15 | E-MTAB-6151 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data