Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Integrative analysis of mRNA and lncRNA profiles identified pathogenetic lncRNAs in esophageal squamous cell carcinoma

ABSTRACT: Integrative analysis of mRNA and lncRNA profiles identified pathogenetic lncRNAs in esophageal squamous cell carcinoma

PROVIDER: PRJNA435587 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Integrative analysis of mRNA and lncRNA profiles identified pathogenetic lncRNAs in esophageal squamous cell carcinoma

Project description:Systems biology approaches can help understand pathogenesis of complex human diseases like cancers for identification of potential new therapeutic targets. Here in this study, we performed genome-wide screening for mRNA and lncRNA profiles in esophageal cancer to identify the novel cancer-related mRNA and lncRNA in esophageal squamous cell carcinoma (ESCC). We identified 3000 up-regulated/2517 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. At last, mRNA and lncRNA co-expression network were built and highly-connected networks were identified, which may provide a mechanism of mRNA expression regulation by lncRNA. To our knowledge, this is the first study to explore the co-expression networks and the lncRNA-mRNA networks could be therapeutic targets for ESCC treatments.

2019-02-23 | GSE111011 | GEO

lncRNAs and mRNAs expression data in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

Project description:The differential expression profile of lncRNAs and mRNAs in esophageal squamous cell carcinoma in high-incidence areas of China was constructed and co-expression correlation analysis was performed. The expression profile of lncRNAs in ESCC tissues was significantly different from that in adjacent normal tissues. Co-expression analysis revealed that lncRNA may be involved in the occurrence and development of esophageal cancer, thus providing a new basis for the diagnosis and treatment of esophageal cancer.

2023-09-10 | GSE157804 | GEO

mRNA expression profiles of 71 esophageal squamous cell carcinoma cases

Project description:Analysis of primary esophageal squamous cell carcinoma (ESCC) from 71 patients in japan. Integrative analysis of gene expression profiles and genomic alterations obtained from array-CGH and NGS provided us new insight into the pathogenesis of ESCC

2013-09-01 | GSE47404 | GEO

Agilent 244K CGH data for esophageal squamous cell carcinoma (ESCC)

2013-09-01 | GSE47630 | GEO

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma.

Project description: Not available

| S-EPMC5337622 | biostudies-literature

Agilent 244K CGH data for esophageal squamous cell carcinoma (ESCC)

Project description:Copy number analysis of primary esophageal squamous cell carcinoma (ESCC) from 40 patients in Japan. Integrative analysis of gene expression profiles and genomic alterations obtained from array-CGH and NGS provided us new insight into the pathogenesis of ESCC. 40 tumor samples were prepared for aCGH analysis. For genome profiling, labeling and hybridization of genomic DNA onto the Agilent-014693 Human Genome Microarray Kit 244K (Agilent Technologies) was performed according to the manufacturer's instructions.

2013-09-01 | E-GEOD-47630 | biostudies-arrayexpress

Identified differentially expressed lncRNAs in type 2 diabetes patients

Project description:Identified differentially expressed lncRNAs in type 2 diabetes patients

| PRJNA555791 | ENA

Identified differentially expressed lncRNAs in Type 1 Diabetes Patients

Project description:Identified differentially expressed lncRNAs in Type 1 Diabetes Patients

| PRJNA534518 | ENA

A Novel LincRNA HERES Epigenetically Regulates Wnt Signaling Pathway via Interaction with EZH2 in Esophageal Squamous Cell Carcinoma

Project description:Esophageal squamous cell carcinoma (ESCC), a major type of primary esophageal cancer in developing countries, displays a very poor clinical outcome in five-year survival rate. Although long non-coding RNAs (lncRNAs) exert critical roles in cancer development, the promising therapeutic targets of ESCC-expressed lncRNAs have not been comprehensively examined and their cancer-driving roles remain largely unknown at the mechanistic level. In this study, we aimed to identify ESCC-driving lncRNAs in the transcriptome level and exploit a therapeutic target with understanidng their modes of action.

2019-10-28 | GSE130078 | GEO

LncrRNA and mRNA expression profiling in human esophageal squamous cancer

Project description:LncRNAs are characterized by transcripts more than 200 nucleotides in length with no or limited protein coding potential, emerging as a novel class of vital regulators in recent years. Aberrant lncRNA and mRNA expression has been linked to various human tumors. This study was aimed to identify new aberrant expression lncRNA and mRNA in esophageal squamous cell carcinoma (ESCC) and invested the potential functions in this tumor.

2016-10-25 | GSE89102 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data