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Development of gene expression signatures in colon tissues from wildtype and CARD9 knockout tumor mice

ABSTRACT: Development of gene expression signatures in colon tissues from wildtype and CARD9 knockout tumor mice

PROVIDER: PRJNA437570 | ENA |

REPOSITORIES: ENA

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Development of gene expression signatures in colon tissues from wildtype and CARD9 knockout tumor mice

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of mRNA expression profile for colon tissues from wildtype and CARD9 knockout mice treated with AOM/DSS

2019-12-05 | GSE111615 | GEO

Colon gene expression signatures in wild type and Card9-/-mice exposed to DSS induced colitis

Project description:It is crucial to decipher the host-microbiota interactions as they are involved in intestinal homeostasis and diseases. Caspase Recruitment Domain 9 (Card9) is an inflammatory bowel disease (IBD) susceptibility gene coding for an adapter protein for innate immunity toward many microorganisms. Card9 mediates colitis recovery via interleukin 22 pathway activation and Card9-/- mice have enhanced susceptibility to colitis. To reveal the mechanisms responsible of this defect in Card9-/-mice, we compared colon transcriptomics in WT and Card9-/- mice before and during DSS-induced colitis. Mice transcriptomes clusterized according to the genotype supporting a pattern clearly different in WT and Card9-/- mice. The number of up-regulated genes at day 7 was largely higher in Card9-/- compared to WT mice. Pathway analyses of the induced transcripts showed a dominance of immune-related pathway with a stronger signal in Card9-/- mice. Interestingly, NOD-like receptor signaling pathway, in which CARD9 is involved, was an exception with weaker activation in Card9-/- than in WT mice. During the recovery period at day 12, pathways involved in cell proliferation and replication were significantly activated in WT compared to Card9-/- mice confirming the healing defect in Card9-/- mice. For the induction of colitis, mice were given drinking water supplemented with 2% (w/v) Dextran sulphate sodium (DSS) for 7 days, then allowed to recover by drinking water alone for 5 additional days. 3 mice of each groups (WT and Card9-/-) were sacrified before DSS administration. 5 WT mice and 4 Card9-/- mice were sacrified 7 days after DSS administration and 5 mice of each group were sacrified at day 12.

2016-04-05 | E-GEOD-67577 | biostudies-arrayexpress

Nrf2 Knockout vs. Wildtype mice

Project description:Nrf2 Knockout vs. Wildtype mice

| PRJNA87883 | ENA

Wildtype and NRP1 knockout macrophages

Project description:Wildtype and NRP1 knockout macrophages

| PRJNA433729 | ENA

Effect of Card9 knockout on gene expression in cardiac tissues of mice post myocardial infarction

Project description:Immune cell infiltration in response to myocyte death contributes to extracellular matrix (ECM) remodeling and scar formation after myocardial infarction (MI). Caspase-recruitment domain protein 9 (CARD9) which belongs to CARD family acts as an adapter that mediate the transduction of proinflammatory signaling cascades in innate immunity. To investigate the role of CARD9 in cardiac injury and repair post ischemia, we subjected Card9 knockout mice to myocardial infarction (MI) , and then performed RNA-seq and gene expression profiling analysis using the ischemic cardiac tissues at 3 days post-MI, to identify key genes and pathways regulated by CARD9.

2023-10-25 | GSE235257 | GEO

AQP8 knockout project - 2DE of wild and AQP8 knockout mice colon

Project description:2DE of wild and AQP8 knockout mice colon

2010-07-01 | PRD000252 | Pride

Nrf2 Knockout vs. Wildtype mice, liver sample

Project description:In situ synthesized oligo arrays, U74Av2, from Affymetrix were used to measure differential gene expression in RNA samples generated from the liver of Nrf2 knockout and wildtype mice at 5 month age. Total RNAs from two Nrf2 knockout or wildtype littermates were analyzed separately. There are two replicates (GSM 13431, 13435) for the female Nrf2 wildtype group, two replicates (GSM 13439, 13441) for the male Nrf2 wildtype group, two replicates (GSM 13436, 13437) for the female Nrf2 knockout group, and two replicates (GSM 13438, 13440) for the male Nrf2 knockout group. Keywords: parallel sample

2003-12-16 | GSE864 | GEO

Pattern of Islr knockout mouse colon gene expression

Project description:To further understand different gene expression of islr knockout mouse colon and normal colon, we have employed colon samples microarray expression profiling as a discovery platform to identify different genes with Islr knockout mouse colon and normal colon. Comparison with normal colon, significantly upgene is 779 and downgene is 996 in knockout group.

2020-03-20 | GSE135259 | GEO

Nrf2 Knockout vs. Wildtype mice, spleen sample

Project description:In situ synthesized oligo arrays, U74Av2, from Affymetrix were used to measure differential gene expression in RNA samples generated from the spleen of Nrf2 knockout and wildtype female mice at 5 month age. Total RNAs from two Nrf2 knockout or wildtype littermates were analyzed separately. There are two replicates (GSM 13470, 13472) for the female Nrf2 wildtype group and two replicates (GSM 13467, 13469) for the female Nrf2 knockout group. Keywords: parallel sample

2003-12-16 | GSE865 | GEO

Wildtype and Gde3 knockout conditioned media from primary astrocyte culture

Project description:Primary astrocyte cultures were prepared from wildtype and Gde3 knockout mouse brain. Conditioned media was collected, concentrated and analyzed using TMT-MS.

2023-03-20 | MSV000091515 | MassIVE

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