Dataset Information


RNA seq analysis on zebrafish Notch 3 mutants and adult neural stem cells

ABSTRACT: RNA seq analysis on zebrafish Notch 3 mutants and adult neural stem cells

ORGANISM(S): Danio rerio  



Dataset's files

Action DRS
SRR6829420_1.fastq.gz Fastqsanger.gz
SRR6829420_2.fastq.gz Fastqsanger.gz
SRR6829411_1.fastq.gz Fastqsanger.gz
SRR6829411_2.fastq.gz Fastqsanger.gz
SRR6829421_1.fastq.gz Fastqsanger.gz
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Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain.

Than-Trong Emmanuel E   Ortica-Gatti Sara S   Mella Sébastien S   Nepal Chirag C   Alunni Alessandro A   Bally-Cuif Laure L  

Development (Cambridge, England) 20180515 10

Neural stem cells (NSCs) in the adult vertebrate brain are found in a quiescent state and can preserve long-lasting progenitor potential (stemness). Whether and how these two properties are linked, and to what extent they can be independently controlled by NSC maintenance pathways, is unresolved. We have previously identified Notch3 signalling as a major quiescence-promoting pathway in adult NSCs of the zebrafish pallium. We now show that Notch3 also controls NSC stemness. Using parallel transcr  ...[more]

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