Genomics

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118

KDM5B decommissions the H3K4 methylation landscape of self-renewal genes during trophoblast stem cell differentiation


ABSTRACT: KDM5B decommissions the H3K4 methylation landscape of self-renewal genes during trophoblast stem cell differentiation

PROVIDER: PRJNA438346 | ENA |

REPOSITORIES: ENA

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KDM5B decommissions the H3K4 methylation landscape of self-renewal genes during trophoblast stem cell differentiation.

Xu Jian J   Kidder Benjamin L BL  

Biology open 20180510 5


Trophoblast stem (TS) cells derived from the trophectoderm (TE) of mammalian embryos have the ability to self-renew indefinitely or differentiate into fetal lineages of the placenta. Epigenetic control of gene expression plays an instrumental role in dictating the fate of TS cell self-renewal and differentiation. However, the roles of histone demethylases and activating histone modifications such as methylation of histone 3 lysine 4 (H3K4me3/me2) in regulating TS cell expression programs, and in  ...[more]

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