Genomics

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Marked Disparity of MicroRNA Modulation by cGMP-selective PDE5 versus PDE9 Inhibitors in Heart Disease


ABSTRACT: Marked Disparity of MicroRNA Modulation by cGMP-selective PDE5 versus PDE9 Inhibitors in Heart Disease

PROVIDER: PRJNA439190 | ENA |

REPOSITORIES: ENA

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Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease.

Kokkonen-Simon Kristen M KM   Saberi Amir A   Nakamura Taishi T   Ranek Mark J MJ   Zhu Guangshuo G   Bedja Djahida D   Kuhn Michaela M   Halushka Marc K MK   Lee Dong Ik DI   Kass David A DA  

JCI insight 20180809 15


MicroRNAs (miRs) posttranscriptionally regulate mRNA and its translation into protein, and are considered master controllers of genes modulating normal physiology and disease. There is growing interest in how miRs change with drug treatment, and leveraging this for precision guided therapy. Here we contrast 2 closely related therapies, inhibitors of phosphodiesterase type 5 or type 9 (PDE5-I, PDE9-I), given to mice subjected to sustained cardiac pressure overload (PO). Both inhibitors augment cy  ...[more]

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