Project description:Although many studies have focused on dimorphic switching, noncoding RNAs in Talaromyces marneffei have been neglected until now. rRNA depletion RNA-seq with or without RNase R treatment were performed in mycelium and yeast conditions of Talaromyces marneffei by to unveil the functions of circRNAs in dimorphic switching.
Project description:Transcriptomic profiling and real-time quantitative reverse transcription-PCR analyses revealed that TP05746 dynamically regulated the expression of genes encoding major PBDEs. Furthermore, in vitro binding experiments confirmed that TP05746 directly bound to the promoter regions of these major enzyme genes. Transcription factors mediated the regulation of plant-biomass-degrading enzyme (PBDE) gene expression in Talaromyces pinophilus.
