Project description:To understand differences of gene expression profiles between Francisella strains RNA profiles of Francisella strains were generated by deep sequencing, in triplicate, using NovaSeq6000. qRT–PCR validation was performed using SYBR Green assays. Our study represents the first detailed differential transcriptomic analysis of Francisella strains , with biologic replicates, generated by RNA-seq technology.

2022-05-31 | GSE174793 | GEO

Coxiella-like endosymbiont isolate:CLERM

Project description:Coxiella-like endosymbiont isolate:CLERM Genome sequencing and assembly

| PRJNA395382 | ENA

Transcription profiling of human monocytes infected with Francisella tularensis

Project description:Differential expression in human peripheral blood monocytes between F. novicida-infected and uninfected, and between Francisella tularensis tularensis isolate Schu S4 and uninfected. The goal was to examine genomewide transcriptional reponses to these two strains, and identify differentially-regulated genes that may help explain the virulence of Schu S4. Experiment Overall Design: Human monocytes were infected with the Schu S4 isolate of Francisella tularensis tularensis (n=4), with F. tularensis subspecies novicida isolate U112 (n=4) or were left uninfected (n=6). Gene expression values were calculated using the gcrma package in R and BioConductor, and limma to identify differentially expressed genes. Submitted here are expression values calculated using R 2.7.1 and BioConductor 2.2 (FreeBSD/amd64) but the original were done using R 2.6.1 and BioConductor 2.1 (FreeBSD/amd64). Twelve other chips were pooled with these 14 for preprocessing.

2008-10-25 | E-GEOD-12108 | biostudies-arrayexpress

Francisella tularensis strain:holacrtica | isolate:12T0050

Project description:Francisella tularensis strain:holacrtica | isolate:12T0050 Genome sequencing and assembly

| PRJNA422969 | ENA

Phosphorylation Francisella

Project description:Francisella possesses a non-canonical T6SS that is essential for efficient phagosomal escape and access to the cytosol of infected macrophages. Using a global and site-specific phosphoproteomic analysis of Francisella we identified here a unique phosphorylation site on IglB, the TssC homologue and a key component of the T6SS contractile sheath. Phosphorylation of the sheath may constitute a previously unrecognized mechanism contributing to the dynamics of assembly-disassembly of the T6SS.

2023-12-20 | PXD012507 | Pride

Francisella tularensis

Project description:Francisella tularsensis Multi-Isolate Genome Sequencing

| PRJNA68685 | ENA

Expression of Wigglesworthia glossinidia endosymbiont of Glossina morsitans morsitans genes

Project description:Transcriptome analysis of Wigglesworthia glossinidia endosymbiont derived from uninfected and infected samples at 3 time points (3, 10 and 20 days). Expression profiling by array - Wigglesworthia glossinidia endosymbiont of Glossina morsitans morsitans

2015-03-10 | GSE55931 | GEO

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