Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [bacterial gene expression]

ABSTRACT: Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [bacterial gene expression]

PROVIDER: PRJNA445875 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners

Project description:Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners

| PRJNA445866 | ENA

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [bacterial gene expression]

Project description:Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis remains unknown. Here, we showed that B. wadsworthia synergize with HFD to promote higher inflammation, intestinal barrier dysfunction and bile acid dysmetabolism, leading to higher glucose dysmetabolism and hepatic steatosis. Host-microbiota transcriptomics analysis unraveled pathways, particularly butanoate metabolism, which may underlie the metabolic effects mediated by B. wadsworthia. Pharmacological suppression of B. wadsworthia-associated inflammation unmasked the bacterium’s intrinsic capacity to induce a negative impact on glycemic control and hepatic function. Finally, the probiotic Lactobacillus rhamnosus CNCM I-3690 was able to limit B. wadsworthia-induced immune and metabolic impairment by limiting its expansion, reducing inflammation and reinforcing intestinal barrier. Our results support a new avenue for interventions against western diet-driven inflammatory and metabolic diseases.

2018-05-26 | GSE112387 | GEO

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [mouse gene expression]

2018-05-26 | GSE111451 | GEO

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [mouse gene expression]

Project description:Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [mouse gene expression]

| PRJNA437083 | ENA

Bilophila wadsworthia

Project description:Bilophila wadsworthia overview

| PRJNA42043 | ENA

Bilophila wadsworthia ATCC 49260

Project description:Bilophila wadsworthia ATCC 49260 Genome sequencing and assembly

| PRJNA223063 | ENA

Project description:Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners.

| PRJEB25364 | ENA

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-05-26 | GSE112388 | GEO