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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [Bisulfite-seq]

ABSTRACT: SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [Bisulfite-seq]

PROVIDER: PRJNA449121 | ENA |

REPOSITORIES: ENA

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [Bisulfite-seq]

Project description:The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. Deficiency in Setd2 leads to extensive alterations of the oocyte epigenome, including the loss of H3K36me3, failure in establishing the correct DNA methylome, invasion of H3K4me3 and H3K27me3 into former H3K36me3 territories and aberrant acquisition of H3K4me3 at imprinting control regions instead of DNA methylation. Importantly, maternal depletion of SETD2 results in oocyte maturation defects and subsequent one-cell arrest after fertilization. The preimplantation arrest is mainly due to a maternal cytosolic defect, since it can be largely rescued by normal oocyte cytosol. However, chromatin defects, including aberrant imprinting, persist in these embryos, leading to embryonic lethality after implantation. Thus, these data identify SETD2 as a crucial player in establishing the maternal epigenome that in turn controls embryonic development.

2019-05-01 | GSE112833 | GEO

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [ChIP-seq]

2019-05-01 | GSE112834 | GEO

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [RNA-seq]

2019-05-01 | GSE112832 | GEO

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

Project description:SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

| PRJNA449119 | ENA

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [RNA-seq]

Project description:SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [RNA-seq]

| PRJNA449120 | ENA

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [ChIP-seq]

Project description:SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [ChIP-seq]

| PRJNA449122 | ENA

Genomic imprinting of Xist by maternal H3K27me3

Project description:Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X chromosome inactivation (XCI) in female mammals. However, the mechanism underlying the Xist imprinting is unclear. Here we show that the Xist gene is coated with H3K27me3 in mouse oocytes, which persists through preimplantation development. Ectopic removal of H3K27me3 induces maternal Xist expression and maternal XCI, indicating that maternal H3K27me3 is the imprinting mark of Xist.

2017-11-09 | GSE103714 | GEO

Maternal methionine supplementation alters the epigenome of the offspring [Bisulfite-Seq]

Project description:Maternal methionine supplementation alters the epigenome of the offspring [Bisulfite-Seq]

| PRJNA481390 | ENA

Maternal to paternal epigenome reprogramming during early sea lamprey (Petromyzon marinus) development (Bisulfite-Seq)

Project description:Maternal to paternal epigenome reprogramming during early sea lamprey (Petromyzon marinus) development

2023-05-26 | GSE220552 | GEO

Maternal gestational nutrition perturbs offspring sperm epigenome in sheep [BiSulfite-seq]

Project description:There is a growing body of evidence that inadequate maternal nutrition during gestation can have immediate and life-long effects on offspring. However, little is known about the reproductive effects of maternal gestational nutrition in offspring males. Here, using a sheep model of poor maternal nutrition (restricted- or over-feeding) during gestation, we found that poor maternal gestational nutrition does not affect semen characteristics (i.e. volume, sperm concentration, pH, sperm motility, sperm morphology) and scrotal circumference in offspring. However, by evaluating associations between poor maternal gestational nutrition and altered small non-cording RNAs (sncRNAs) and DNA methylation in offspring sperm, we demonstrated that poor maternal gestational nutrition alters sperm sncRNA composition and expression. Whole genome bisulfite sequencing further identified genomic regions with increased or decreased DNA methylation in sperm in response to poor maternal gestational nutrition. These findings imply that maternal diet-induced epigenetic errors can accumulate in sperm to worsen developmental outcomes of future generations.

2024-04-04 | GSE225924 | GEO

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