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Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence [methylation - recurrence]

ABSTRACT: Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence [methylation - recurrence]

PROVIDER: PRJNA449765 | ENA |

REPOSITORIES: ENA

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Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence

Project description:Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence

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Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence [methylation - classification]

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Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence [methylation - recurrence]

Project description:Hepatocellular carcinoma (HCC) is a heterogeneous disease with a variety of etiological factors, and ranks as the second leading cause of cancer-related mortality worldwide due to multifocal recurrence. Comprehensive molecular evaluation of HCC by multiplatform analysis defined three major subtypes: (1) mitogenic and stem cell-like tumors with chromosomal instability; (2) CTNNB1-mutated tumors displaying DNA hypermethylation; and (3) metabolic syndrome-associated tumors, which included an immunogenic subgroup characterized by macrophage infiltration and favorable prognosis. Although genomic and epigenomic analysis explicitly discriminated HCC with intrahepatic metastasis (IM) from multicentric HCC (MC), the phenotypic similarity between the primary and recurrent tumors was not linked to the IM/MC diagnosis, but rather the integrated classification. Thus, identification of these HCC subtypes provides insights into patient stratification and opportunities for therapeutic development.

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Epigenetic inheritance mediates phenotypic evolution in natural populations

Project description:Genetic variation is regarded as a prerequisite for evolution. Theoretical models suggest epigenetic information inherited independently of DNA sequence can also enable evolution. However, whether epigenetic inheritance mediates phenotypic evolution in natural populations is unknown. Here we show that natural epigenetic DNA methylation variation in gene bodies regulates genes expression, and thereby influences the natural variation of complex traits in Arabidopsis thaliana. Notably, the effects of methylation variation on phenotypic diversity and gene expression variance are comparable with those of DNA sequence polymorphism. We also identify methylation epialleles in numerous genes associated with environmental conditions in native habitats, suggesting that intragenic methylation facilitates adaptation to fluctuating environments. Our results demonstrate that methylation variation fundamentally shapes phenotypic diversity in natural populations and provides an epigenetic basis for adaptive Darwinian evolution independent of genetic polymorphism.

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Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-01-03 | GSE112791 | GEO