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Distinct macrophage populations upon physiological changes in adipose tissue [ATAC-seq]

ABSTRACT: Distinct macrophage populations upon physiological changes in adipose tissue [ATAC-seq]

OTHER RELATED OMICS DATASETS IN: GSE113583GSE113594GSE113595

PROVIDER: PRJNA453154 | ENA |

REPOSITORIES: ENA

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Similar Datasets

Distinct macrophage populations upon physiological changes in adipose tissue

Project description:Distinct macrophage populations upon physiological changes in adipose tissue

| PRJNA453182 | ENA

Distinct macrophage populations upon physiological changes in adipose tissue [scRNA-seq]

Project description:Distinct macrophage populations upon physiological changes in adipose tissue [scRNA-seq]

| PRJNA451512 | ENA

Distinct macrophage populations upon physiological changes in adipose tissue [RNA-seq]

Project description:Distinct macrophage populations upon physiological changes in adipose tissue [RNA-seq]

| PRJNA453187 | ENA

Distinct macrophage populations upon physiological changes in adipose tissue [RNA-seq]

Project description:We report that obese fat tissue of mice contain multiple distinct populations of adipose tissue macrophage (ATM) with unique transcriptomes and chromatin landscapes. Mouse Ly6c ATMs express genes that are adipogenic, while CD9 ATMs express pro-inflammatory genes under the control of activating transcription factors. Adoptive transfer of Ly6c ATMs into lean mice activates gene programs typical of normal adipocyte physiology. By contrast, adoptive transfer of CD9 ATMs drives gene expression that is characteristic of obesity.

2018-06-04 | GSE113594 | GEO

Distinct macrophage populations upon physiological changes in adipose tissue [ATAC-seq]

2018-06-04 | GSE113583 | GEO

Distinct macrophage populations upon physiological changes in adipose tissue [scRNA-seq]

2018-06-04 | GSE113560 | GEO

Distinct macrophage populations upon physiological changes in adipose tissue

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-04 | GSE113595 | GEO

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue.

Project description: Not available

| S-EPMC5984532 | biostudies-literature

Visceral adipose tissue macrophage subsets

Project description:Visceral adipose tissue macrophage subsets

| PRJNA484897 | ENA

RNASeq profiles from two distinct F4/80+VCAM1+ sorted bone marrow populations are consistent with non-macrophage cells coated with macrophage fragments

Project description:The objective of this study was to characterise macrophage subsets in bone marrow (BM) isolated from Csf1r-EGFP mice. A concurrent imaging flow cytometry study conducted by our team unexpectedly revealed macrophage surface marker staining emanates from membrane-bound subcellular remnants associated with unrelated cells. Expression data from sorted BM “macrophage” populations was found to be consistent with macrophage fragments associated with non-macrophage cells. Granulocyte-specific genes were enriched within the CD11b+ “macrophage” (CD11b+F4/80+Ly6G-GFPloVCAM1+) populations, whereas CD11b- “macrophages” (CD11b-F4/80+GFP+VCAM1+) were consistent with a mixed cell population including both plasma cells and erythroblasts. This data demonstrates how fragmentation of hematopoietic tissue macrophages can result in misattribution of macrophage identity to non-macrophage populations, thereby undermining accuracy of macrophage ex vivo molecular profiles.

2021-11-05 | GSE187052 | GEO

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