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MicroRNA expression profiling of papillary thyroid carcinoma (PTC) and matched adjacent normal thyroid tissues

ABSTRACT: microRNA expression profiling of papillary thyroid carcinoma (PTC) and matched adjacent normal thyroid tissues

PROVIDER: PRJNA453477 | ENA |

REPOSITORIES: ENA

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microRNA expression profiling of papillary thyroid carcinoma (PTC) and matched adjacent normal thyroid tissues

Project description:We profiled the microRNA expression of 5 pairs of PTC and normal thyroid tissues. All the tissues were immediately snap-frozen in liquid nitrogen and confirmed as papillary thyroid carcinoma by expert pathologists. Numerous deregulated mature microRNAs were identified comparing PTC tissues versus normal thyroid tissues. Details about the clinical-pathological characteristics of the samples are also provided.

2019-03-06 | GSE113629 | GEO

circRNAs and papillary thyroid cancer

Project description:The dysregulation of circular RNAs (circRNAs) has been implicated in the development and progression of papillary thyroid cancer (PTC). In this study, we analyzed the dysregulated circRNA profile using PTC tissues and matched adjacent normal tissues by RNA-seq.

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Next Generation Sequencing of Papillary Thyroid Cancer tissue sample and adjacent normal tissue

Project description:Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of Papillary Thyroid Cancer tissue sample and adjacent normal tissue. The goals of this study are to analysis the different circRNAs expression between Cancer tissue sample and adjacent normal tissue. Quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods and to evaluate protocols for optimal high-throughput data analysis. We performed circRNA-seq in Papillary Thyroid Cancer tissue sample and adjacent normal tissue. We found that through the deep sequencing of four pairs PTC and adjacent nontumor tissues, we identified 16569 circRNAs, 720 circRNAs were differentials expressed, among them, 301 upregulated and 419 downregulated.

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Sporadic and Post-Chernobyl Papillary Thyroid Cancers

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