Project description:Neuronal cell diversity is essential to endow distinct brain regions with specific functions. During development, progenitors within these regions are characterised by specific gene expression programs, contributing to the generation of diversity in postmitotic neurons and glia. While the region-specific molecular diversity of neurons and astrocytes is increasingly understood, whether these cells share region-specific programs remains unknown. Here, we show that in the neocortex and thalamus, neurons and astrocytes express shared region-specific transcriptional and epigenetic signatures. These signatures not only distinguish cells across brain regions but are also detected across substructures within regions, such as distinct thalamic nuclei, where clonal analysis reveals the existence of common nucleus-specific progenitors for neurons and glia. Consistent with their shared molecular signature, regional specificity is maintained following astrocyte-to-neuron reprogramming. A detailed understanding of these regional-specific signatures may thus inform strategies for future cell-based brain repair.

2021-05-18 | GSE138976 | GEO

Astrocytes and neurons share brain region-specific transcriptional signatures (RNAseq: Astrocytes)

2021-05-18 | GSE135602 | GEO

Genome-wide transcriptome analysis of a specific brain region (ICo) in chickens

Project description:We compared the gene expression of ICo (center of rooster crowing) using RNA-seq between the two comparison groups showing and not showing crowing and uncovered the molecular basis on animal vocalization.

2019-12-26 | GSE113699 | GEO

Astrocytes and neurons share brain region-specific transcriptional signatures (RNAseq: Astrocytes)

Project description:Astrocytes and neurons share brain region-specific transcriptional signatures (RNAseq: Astrocytes)

| PRJNA559392 | ENA

Astrocytes and neurons share brain region-specific transcriptional signatures (RNAseq: NeuronsP0)

Project description:Astrocytes and neurons share brain region-specific transcriptional signatures (RNAseq: NeuronsP0)

| PRJNA577915 | ENA

Region-specific DNA-binding properties of NFIA in the adult mouse brain

Project description:Region-specific DNA-binding properties of NFIA in the adult mouse brain

| PRJNA609158 | ENA